| Blastomycosis in immunosuppressed patients. | |
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MedLine Citation:
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PMID: 6950684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Of 78 patients with blastomycosis, 3 patients had received glucocorticoid therapy prior to diagnosis and 3 others had an underlying hematologic malignancy (chronic lymphocytic leukemia, chronic myelogenous leukemia, multiple myeloma). The clinical picture in these 6 patients was similar to blastomycosis in nonimmunosuppressed patients (in contrast to histoplasmosis or coccidioidomycosis in immunosuppressed patients in whom a distinct clinical syndrome is often seen). The patients presented with chronic pulmonary infiltrates or with isolated skin ulcers. The response to therapy was good if the diagnosis was made early. Blastomycosis can occur in immunosuppressed patients. However, the spectrum of underlying illness is not that seen in opportunistic histoplasmosis or coccidioidomycosis, where patients with T-cell defects predominate. Possible explanations for the rarity of blastomycosis in more classically T-cell-immunosuppressed patients are discussed. |
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Authors:
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L D Recht; S F Davies; M R Eckman; G A Sarosi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American review of respiratory disease Volume: 125 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1982 Mar |
Date Detail:
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Created Date: 1982-05-27 Completed Date: 1982-05-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 359-62 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amphotericin B / therapeutic use Blastomycosis / complications, diagnosis, immunology* Female Humans Immunosuppression* Leukemia / complications* Leukemia, Myeloid / complications Male Middle Aged Multiple Myeloma / complications* Prednisone / therapeutic use |
| Chemical | |
Reg. No./Substance:
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1397-89-3/Amphotericin B; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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