Document Detail


Blastomycosis in immunosuppressed patients.
MedLine Citation:
PMID:  6950684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Of 78 patients with blastomycosis, 3 patients had received glucocorticoid therapy prior to diagnosis and 3 others had an underlying hematologic malignancy (chronic lymphocytic leukemia, chronic myelogenous leukemia, multiple myeloma). The clinical picture in these 6 patients was similar to blastomycosis in nonimmunosuppressed patients (in contrast to histoplasmosis or coccidioidomycosis in immunosuppressed patients in whom a distinct clinical syndrome is often seen). The patients presented with chronic pulmonary infiltrates or with isolated skin ulcers. The response to therapy was good if the diagnosis was made early. Blastomycosis can occur in immunosuppressed patients. However, the spectrum of underlying illness is not that seen in opportunistic histoplasmosis or coccidioidomycosis, where patients with T-cell defects predominate. Possible explanations for the rarity of blastomycosis in more classically T-cell-immunosuppressed patients are discussed.
Authors:
L D Recht; S F Davies; M R Eckman; G A Sarosi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  125     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  359-62     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amphotericin B / therapeutic use
Blastomycosis / complications,  diagnosis,  immunology*
Female
Humans
Immunosuppression*
Leukemia / complications*
Leukemia, Myeloid / complications
Male
Middle Aged
Multiple Myeloma / complications*
Prednisone / therapeutic use
Chemical
Reg. No./Substance:
1397-89-3/Amphotericin B; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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