Document Detail

Blastoid Variant Mantle Cell Lymphoma with Complex Karyotype Including 11q Duplication.
MedLine Citation:
PMID:  25330523     Owner:  NLM     Status:  Publisher    
We describe a case of blastoid mantle cell lymphoma with a complex karyotype. The blastoid variant is a rare type of non-Hodgkin lymphoma exhibiting an aggressive clinical course. Mantle cell lymphoma is a distinct entity of mature B-cell neoplasms genetically characterized by the presence of t(11;14). In the present case, conventional analysis revealed structural abnormalities of chromosomes 2, 4, 6, 10, 13, and 19, along with 3 additional marker chromosomes. The derivative 1 chromosome determined in the case was a result of t(1p;11q). Our interesting finding was the presence of a different translocation between 11q and chromosome 1 in addition to t(11;14). Thus, the resulting 11q duplication was believed to additionally increase the enhanced expression of cyclin D1 gene, which is responsible in the pathogenesis of the disease. Fluorescence in situ hybridization method by the t(11;14) probe revealed clonal numerical abnormalities of chromosomes 11 and 14 in some cells. The detection of multiple abnormalities explains the bad prognosis in the present case. On the basis of our findings, we can easily conclude that results of cytogenetic analyses of similar mantle cell lymphoma patients would provide clues about new responsible gene regions and disease prognosis. In conclusion, it has been suggested that the presence of multiple chromosomal aberrations in addition to the specific t(11;14) may have a negative impact on clinical course and survival rate.
Abstract available from the publisher.
Ozge Ozer; Selami Koçak Toprak; Enver Ote; Zerrin Yılmaz; Feride Iffet Sahin
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Publication Detail:
Journal Detail:
Title:  Turkish journal of haematology : official journal of Turkish Society of Haematology     Volume:  31     ISSN:  1300-7777     ISO Abbreviation:  Turk J Haematol     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-10-20     Completed Date:  -     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9606065     Medline TA:  Turk J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  290-294     Citation Subset:  -    
Vernacular Title:
11q Duplikasyonu İçeren Kompleks Karyotipe Sahip Bir Blastoid Varyant Mantle Hücreli Lenfoma.
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