Document Detail

Blastocyst culture and transfer: lessons from an unselected, difficult IVF population.
MedLine Citation:
PMID:  18681996     Owner:  NLM     Status:  MEDLINE    
Blastocyst-stage transfer has yielded excellent results in good prognosis IVF patients, but its efficacy in the general IVF population has not been clearly demonstrated. The objective of this study was to compare cleavage-stage and blastocyst-stage transfer in a mixed, general IVF population. In a prospective, quasi-randomized study, 152 patients underwent 164 treatment cycles. Patients were allocated to cleavage-stage (group 1; n = 94) or blastocyst-stage (group 2; n = 70) transfer. Main outcome measures included implantation, clinical pregnancy and live birth rates. Implantation (11.2% versus 15.5%), clinical pregnancy (34% versus 21%) and live birth rates per transfer (21.3% versus 13.8%) and per started cycle (21.3% versus 11.4%) were all comparable for groups 1 and 2, respectively. Logistic regression analysis revealed that blastocyst culture and transfer reduced the odds for pregnancy in the general IVF population and defined a good prognosis group for blastocyst transfer. Introducing blastocyst culture and transfer to all IVF patients is not advantageous. Blastocyst transfer should be offered primarily to good prognosis patients, and this group should be specifically defined in each clinical set-up.
Ariel Weissman; Galia Biran; Hana Nahum; Marek Glezerman; David Levran
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  17     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-06     Completed Date:  2008-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, IVF Unit, Wolfson Medical Centre, Holon, Israel.
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MeSH Terms
Blastocyst / cytology
Cell Count
Cleavage Stage, Ovum / physiology
Embryo Culture Techniques / methods*
Embryo Implantation / physiology
Embryo Transfer / methods*
Fertilization in Vitro / methods*
Pregnancy Rate
Treatment Failure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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