| Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus. | |
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MedLine Citation:
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PMID: 11213287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 microM. |
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Authors:
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S Sakuda; M Ono; H Ikeda; T Nakamura; Y Inagaki; R Kawachi; J Nakayama; A Suzuki; A Isogai; H Nagasawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of antibiotics Volume: 53 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-02-12 Completed Date: 2001-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 1265-71 Citation Subset: IM |
Affiliation:
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Department of Applied Biological Chemistry, The University of Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxins
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antagonists & inhibitors*,
biosynthesis Anti-Bacterial Agents / chemistry, pharmacology* Aspergillus / drug effects*, metabolism Molecular Structure Pyrrolidinones / chemistry, pharmacology* Spectrum Analysis |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins; 0/Anti-Bacterial Agents; 0/Pyrrolidinones; 0/blasticidin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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