Document Detail


Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus.
MedLine Citation:
PMID:  11213287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 microM.
Authors:
S Sakuda; M Ono; H Ikeda; T Nakamura; Y Inagaki; R Kawachi; J Nakayama; A Suzuki; A Isogai; H Nagasawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  53     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-12     Completed Date:  2001-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1265-71     Citation Subset:  IM    
Affiliation:
Department of Applied Biological Chemistry, The University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aflatoxins / antagonists & inhibitors*,  biosynthesis
Anti-Bacterial Agents / chemistry,  pharmacology*
Aspergillus / drug effects*,  metabolism
Molecular Structure
Pyrrolidinones / chemistry,  pharmacology*
Spectrum Analysis
Chemical
Reg. No./Substance:
0/Aflatoxins; 0/Anti-Bacterial Agents; 0/Pyrrolidinones; 0/blasticidin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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