Document Detail


Blast wave exposure impairs memory and decreases axon initial segment length.
MedLine Citation:
PMID:  23025758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exposure to a blast wave has been proposed to cause mild traumatic brain injury (mTBI), with symptoms including altered cognition, memory, and behavior. This idea, however, remains controversial, and the mechanisms of blast-induced brain injury remain unknown. To begin to resolve these questions, we constructed a simple compressed air shock tube, placed rats inside the tube, and exposed them to a highly reproducible and controlled blast wave. Consistent with the generation of a mild injury, 2 weeks after exposure to the blast, we found that motor performance was unaffected, and a panel of common injury markers showed little or no significant changes in expression in the cortex, corpus callosum, or hippocampus. Similarly, we were unable to detect elevated spectrin breakdown products in brains collected from blast-exposed rats. Using an object recognition task, however, we found that rats exposed to a blast wave spent significantly less time exploring a novel object when compared with control rats. Intriguingly, we also observed a significant shortening of the axon initial segment (AIS) in both the cortex and hippocampus of blast-exposed rats, suggesting altered neuronal excitability after exposure to a blast. A computational model showed that shortening the AIS increased both threshold and the interspike interval of repetitively firing neurons. These results support the conclusion that exposure to a single blast wave can lead to mTBI with accompanying cognitive impairment and subcellular changes in the molecular organization of neurons.
Authors:
Kelli L Baalman; R James Cotton; S Neil Rasband; Matthew N Rasband
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-02-06
Journal Detail:
Title:  Journal of neurotrauma     Volume:  30     ISSN:  1557-9042     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-12-18     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  741-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / pathology*
Blast Injuries / complications,  pathology*,  physiopathology
Brain Concussion / complications*,  pathology*,  physiopathology
Computer Simulation
Disease Models, Animal
Fluorescent Antibody Technique
Immunoblotting
Male
Memory Disorders / etiology*,  pathology,  physiopathology
Models, Neurological
Rats
Rats, Sprague-Dawley
Comments/Corrections

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