Document Detail

Blast-induced biomechanical loading of the rat: experimental and anatomically accurate computational blast injury model.
MedLine Citation:
PMID:  22620716     Owner:  NLM     Status:  Publisher    
Blast waves generated by improvised explosive devices (IEDs) cause traumatic brain injury (TBI) in soldiers and civilians. In vivo animal models in conjunction with shock tubes are extensively used in laboratories to simulate field conditions, to identify mechanisms of injury, and to develop injury thresholds. In this paper, we place rats in different placement locations along the length of the shock tube i.e., inside, outside and near the exit, to examine the role of animal placement location (APL) on the biomechanical load experienced by the animal. We found that the biomechanical load on the brain and internal organs in the thoracic cavity (lungs, heart) varied significantly depending on the APL. When the specimen is positioned outside, organs in the thoracic cavity experience a higher pressure for a longer duration, in contrast to APL inside the shock tube. This in turn will possibly alter the injury type, severity and lethality. It is found that the optimal APL occurs where the Friedlander waveform is first formed way inside the shock tube. Once the optimal APL was determined, the effect of the incident blast intensity on the surface and intracranial pressure was measured and analyzed. Noticeably, surface and intracranial pressure scales linearly with the incident peak overpressures, though surface pressures are significantly higher than the other two. Further, we developed and validated an anatomically accurate finite element model of the rat head. With this model, we determined that the main pathway of pressure transmission to the brain was through the skull and not through the snout; however, snout plays a secondary role in diffracting the incoming blast wave towards the skull.
Aravind Sundaramurthy; Aaron Alai; Shailesh Ganpule; Aaron Holmberg; Erwan Plougonven; Namas Chandra
Related Documents :
2143766 - Response of atrial natriuretic factor to postural change in patients with heart failure...
2940286 - Atrial pressure and secretion of atrial natriuretic factor into the human central circu...
11797996 - Different patterns of angiotensin ii and atrial natriuretic peptide secretion in a shee...
1838026 - Developing essential hypertension: a syndrome involving anf deficiency?
1112126 - The unreliability of the maximal midexpiratory flow as an index of acute airway changes.
19254206 - Efficacy and safety of losartan 100 mg or losartan 100 mg plus hydrochlorothiazide 25 m...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-24
Journal Detail:
Title:  Journal of neurotrauma     Volume:  -     ISSN:  1557-9042     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Nebraska Lincoln, Department of Mechanical and Materials Engineering, Lincoln, Nebraska, United States;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synthesis, Structure, Magnetic Behavior, and Theoretical Analysis of Diazine-Bridged Magnetic Ladder...
Next Document:  Treatment of Reticular and Telangiectatic Leg Veins: Double-Blind, Prospective Comparative Trial of ...