Document Detail

Blast cells with nuclear extrusions in the form of micronuclei are associated with MYC amplification in acute myeloid leukemia.
MedLine Citation:
PMID:  18656691     Owner:  NLM     Status:  MEDLINE    
We report three cases of acute myeloid leukemia without maturation [AML-M1 subtype according to the French-American-British classification (FAB)] with the presence of MYC oncogene amplification in form of double minutes (dmin) or homogeneously staining region (hsr). Blasts cells showed a particular morphology with extrusion of chromatin material. We observed by FISH the phenomenon of MYC aggregation in interphase cells and the formation of micronuclei excluded from the nucleus. The appearance of chromatin extrusion in cytological analysis should draw attention of the presence of dmin aggregation and possible MYC amplification.
Olaya Villa; Marta Salido; María Encarnación Pérez-Vila; Ana Ferrer; Leonor Arenillas; Carmen Pedro; Blanca Espinet; Cristina Corzo; Sergi Serrano; Soledad Woessner; Lourdes Florensa; Francesc Solé
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  185     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-08-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-6     Citation Subset:  IM    
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia. Hospital del Mar, URNHE, URTTS, PRBB-IMIM, Pg. Maritim 25-29, 08003 Barcelona, Spain.
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MeSH Terms
Cell Nucleus / genetics,  pathology*
Chromatin / chemistry
Chromosome Aberrations
Chromosome Painting
Cytogenetic Analysis
Fatal Outcome
Follow-Up Studies
Gene Amplification
Genes, myc*
Leukemia, Myeloid, Acute / blood*,  classification,  diagnosis,  genetics*,  pathology*,  therapy
Middle Aged
Remission Induction
Time Factors
Reg. No./Substance:

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