Document Detail


Bladder volume-dependent excitatory and inhibitory influence of lumbosacral dorsal and ventral roots on bladder activity in rats.
MedLine Citation:
PMID:  17878597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was undertaken to examine the role of the afferent and efferent pathways of the lumbosacral spinal nerve roots in the tonic control of bladder activity. Changes of isovolumetric bladder activity were recorded in 21 sympathectomized female rats under urethane anesthesia following transection of the dorsal (DRT) and ventral (VRT) lumbosacral spinal roots, and after intraperitoneal administration of hexamethonium. DRT altered the baseline intravesical pressure in a bladder volume-dependent manner in each animal. The percent change of baseline pressure after VRT following DRT was also dependent upon bladder volume. The percent change of baseline pressure after VRT alone was similarly dependent on bladder volume, but not after VRT followed by DRT. The percent change of baseline intravesical pressure (y)(-9 to +8 cm H(2)O, -56 to +46%) after DRT and VRT depended upon bladder volume (x)(y = 44.7 x -40.4) in all rats. Hexamethonium increased the amplitude of small myogenic bladder contractions after DRT and VRT. In conclusion, the bladder is tonically excited or inhibited by a local reflex pathway and by a parasympathetic reflex pathway that depends on connections with the lumbosacral spinal cord and the pelvic nerves. Both reflex mechanisms are influenced by bladder volume.
Authors:
Kimio Sugaya; William C de Groat
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomedical research (Tokyo, Japan)     Volume:  28     ISSN:  0388-6107     ISO Abbreviation:  Biomed. Res.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2007-10-23     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8100317     Medline TA:  Biomed Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  169-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Ganglionic Blockers / pharmacology
Hexamethonium / pharmacology
Lumbosacral Region / physiology*
Muscle Contraction / drug effects,  physiology*
Organ Size / drug effects,  physiology
Parasympathetic Nervous System / physiology*
Rats
Rats, Sprague-Dawley
Reflex / drug effects,  physiology
Spinal Nerve Roots / physiology*
Sympathectomy
Urinary Bladder / innervation*,  physiology
Grant Support
ID/Acronym/Agency:
DK-49430/DK/NIDDK NIH HHS; R37 DK049430/DK/NIDDK NIH HHS; R37 DK049430-11/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Ganglionic Blockers; 3C9PSP36Z2/Hexamethonium
Comments/Corrections

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