| Bladder volume-dependent excitatory and inhibitory influence of lumbosacral dorsal and ventral roots on bladder activity in rats. | |
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MedLine Citation:
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PMID: 17878597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken to examine the role of the afferent and efferent pathways of the lumbosacral spinal nerve roots in the tonic control of bladder activity. Changes of isovolumetric bladder activity were recorded in 21 sympathectomized female rats under urethane anesthesia following transection of the dorsal (DRT) and ventral (VRT) lumbosacral spinal roots, and after intraperitoneal administration of hexamethonium. DRT altered the baseline intravesical pressure in a bladder volume-dependent manner in each animal. The percent change of baseline pressure after VRT following DRT was also dependent upon bladder volume. The percent change of baseline pressure after VRT alone was similarly dependent on bladder volume, but not after VRT followed by DRT. The percent change of baseline intravesical pressure (y)(-9 to +8 cm H(2)O, -56 to +46%) after DRT and VRT depended upon bladder volume (x)(y = 44.7 x -40.4) in all rats. Hexamethonium increased the amplitude of small myogenic bladder contractions after DRT and VRT. In conclusion, the bladder is tonically excited or inhibited by a local reflex pathway and by a parasympathetic reflex pathway that depends on connections with the lumbosacral spinal cord and the pelvic nerves. Both reflex mechanisms are influenced by bladder volume. |
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Authors:
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Kimio Sugaya; William C de Groat |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomedical research (Tokyo, Japan) Volume: 28 ISSN: 0388-6107 ISO Abbreviation: Biomed. Res. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-09-19 Completed Date: 2007-10-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8100317 Medline TA: Biomed Res Country: Japan |
Other Details:
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Languages: eng Pagination: 169-75 Citation Subset: IM |
Affiliation:
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Division of Urology, Department of Organ-oriented Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. sugaya@med.u-ryukyu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Ganglionic Blockers / pharmacology Hexamethonium / pharmacology Lumbosacral Region / physiology* Muscle Contraction / drug effects, physiology* Organ Size / drug effects, physiology Parasympathetic Nervous System / physiology* Rats Rats, Sprague-Dawley Reflex / drug effects, physiology Spinal Nerve Roots / physiology* Sympathectomy Urinary Bladder / innervation*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK-49430/DK/NIDDK NIH HHS; R37 DK049430-11/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ganglionic Blockers; 60-26-4/Hexamethonium |
| Comments/Corrections | |
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