| Bladder and urethral sphincter function after radical retropubic prostatectomy: a prospective long-term study. | |
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MedLine Citation:
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PMID: 18006215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In a prospective study we analysed the 3-yr results of the effects of radical retropubic prostatectomy (RRP) on detrusor and sphincter function by comparing urodynamic status preoperatively with that during longitudinal follow-up. METHODS: Fifty-four consecutive patients underwent urodynamics with pressure flow studies and Valsalva leak point pressure measurements 3-7 d before RRP (baseline), and then 8 mo after surgery. Thirty-two patients were studied again 3 yr later. We analysed bladder compliance, detrusor overactivity (DO), detrusor contractility, and intrinsic sphincter deficiency (ISD). RESULTS: There was a significant increase in the number of patients with reduced bladder compliance at the 8-mo follow-up. De novo reduced bladder compliance was detected in 32.3% of patients and persisted in 28.1% at the 36-mo follow-up. De novo detrusor hypocontractility was observed in 51% of patients at 8 mo (p<0.05) and persisted in 25% of cases 3 yr later. No patients showed any postvoid residual volume. The associations between detrusor hypocontractility with DO and between detrusor hypocontractility with ISD were detected in 76.2% and 44% of patients, respectively, at 8 mo, and in 25% and in 34% of cases, respectively, at 36 mo of follow-up (p<0.05 and p<0.001). CONCLUSIONS: Following RRP detrusor hypocontractility, decreased bladder compliance, and ISD represent de novo dysfunction probably due to bladder denervation during surgery. They become established conditions over time in about 30% of patients. Nevertheless, they do not produce voiding symptoms because patients develop new voiding behaviours. |
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Authors:
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Antonella Giannantoni; Ettore Mearini; Alessandro Zucchi; Elisabetta Costantini; Luigi Mearini; Vittorio Bini; Massimo Porena |
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Publication Detail:
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Type: Journal Article Date: 2007-11-05 |
Journal Detail:
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Title: European urology Volume: 54 ISSN: 0302-2838 ISO Abbreviation: Eur. Urol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7512719 Medline TA: Eur Urol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 657-64 Citation Subset: IM |
Affiliation:
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Department of Urology and Andrology, University of Perugia, Perugia, Italy. agianton@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chi-Square Distribution Follow-Up Studies Humans Longitudinal Studies Male Prospective Studies Prostatectomy / adverse effects, methods* Prostatic Neoplasms / physiopathology*, surgery* Statistics, Nonparametric Treatment Outcome Urethra / physiopathology* Urinary Bladder / physiopathology* Urination Disorders / etiology, physiopathology Urodynamics |
| Comments/Corrections | |
Comment In:
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Eur Urol. 2008 Sep;54(3):664
[PMID:
18006211
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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