Document Detail

Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin.
MedLine Citation:
PMID:  5411626     Owner:  NLM     Status:  MEDLINE    
Papillary transitional cell tumors were found in the urinary bladders in 8 rats out of 80 that received 2600 milligrams per kilogram of body weight per day of a mixture of sodium cyclamate and sodium saccharin (10:1) for up to 105 weeks. From week 79 on, several of these rats received cyclohexylamine hydrochloride (125 milligrams per kilogram per day, the molecular equivalent of the conversion of about 10 percent of the cyclamate dosage to cyclohexylamine) in addition to the sodium cyclamate and sodium saccharin. In another study in which 50 rats were fed daily 15 milligrams of cyclohexylamine sulfate per kilogram of body weight for 2 years, eight males and nine females survived. One of the eight males had a tumor of the urinary bladder. In neither study were bladder tumors found in the control rats or in rats treated with lower doses of the compounds.
J M Price; C G Biava; B L Oser; E E Vogin; J Steinfeld; H L Ley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  167     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1970 Feb 
Date Detail:
Created Date:  1970-03-05     Completed Date:  1970-03-05     Revised Date:  2011-09-27    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1131-2     Citation Subset:  IM    
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MeSH Terms
Animal Feed
Body Weight
Carcinoma, Papillary / chemically induced*
Carcinoma, Transitional Cell / chemically induced*
Legislation, Drug
Sweetening Agents* / metabolism
United States
Urinary Bladder Neoplasms / chemically induced*
Reg. No./Substance:
0/Amines; 0/Cyclohexanes; 0/Sweetening Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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