Document Detail

Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges.
MedLine Citation:
PMID:  23052956     Owner:  NLM     Status:  MEDLINE    
PURPOSE: A fall in tissue oxygen tension (tPO(2)) is an early indicator of organ hypoxia in both patients and animal models. We previously demonstrated the utility of bladder tPO(2) in various rodent shock models. As a prelude to clinical testing, we aimed to provide further validation of bladder tPO(2) monitoring in a large animal model undergoing a range of cardiorespiratory insults and vasoactive drug interventions.
METHODS: Anaesthetized, mechanically ventilated, instrumented female pigs (n = 8) were subjected to a range of short-term cardiorespiratory (changes in inspired oxygen concentration (FiO(2)), haemorrhage, positive end-expiratory pressure) and pharmacologic (inotrope, pressor) challenges. Global haemodynamics, arterial and pulmonary blood gases and bladder tPO(2) were measured before and after each challenge.
RESULTS: Bladder tPO(2) values fell in line with increasing degrees of hypoxaemia and haemorrhage, and were restored during resuscitation. These changes often preceded those seen in global haemodynamics, arterial base excess and lactate. The rise in bladder tPO(2) with hyperoxia, performed as an oxygen challenge test, was incrementally blunted by progressive haemorrhage. Dobutamine and norepinephrine both increased cardiac output and global O(2) delivery, but had no effect on bladder tPO(2) or lactataemia in these healthy pigs.
CONCLUSIONS: In this pig model bladder tPO(2) provides a sensitive indicator of organ hypoxia compared to traditional biochemical markers during various cardiorespiratory challenges. This technique offers a potentially useful tool for clinical monitoring.
Alex Dyson; Florian Simon; Andrea Seifritz; Olga Zimmerling; José Matallo; Enrico Calzia; Peter Radermacher; Mervyn Singer
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-11
Journal Detail:
Title:  Intensive care medicine     Volume:  38     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-24     Completed Date:  2013-04-10     Revised Date:  2013-05-08    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1868-76     Citation Subset:  IM    
Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK.
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MeSH Terms
Anoxia / diagnosis*
Biological Markers
Cardiotonic Agents / pharmacology
Hemorrhage / physiopathology
Oxygen / metabolism*
Partial Pressure
Pulmonary Gas Exchange
Sensitivity and Specificity
Sus scrofa
Urinary Bladder / blood supply*
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Biological Markers; 0/Cardiotonic Agents; 0/Vasoconstrictor Agents; 7782-44-7/Oxygen
Erratum In:
Intensive Care Med. 2013 Apr;39(4):797
Note: Dosage error in article text

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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