Document Detail

Blackberry-induced hand-foot skin reaction to sunitinib.
MedLine Citation:
PMID:  18998055     Owner:  NLM     Status:  MEDLINE    
Sunitinib is an orally administered small molecule that was approved by the US Food and Drug Administration in January 2006 as monotherapy for the treatment of patients with advanced renal cell carcinoma (RCC) and patients with gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate. Data pooled from multiple sunitinib dose-escalation trials showed that sunitinib is associated with various adverse events, with HFSR occurring in up to 20% of patients. We describe a 48-year-old woman with a history of metastatic colorectal cancer treated with single-agent sunitinib who developed pain and tenderness in areas of friction secondary to Blackberry use, and was diagnosed with trauma-induced hand-foot skin reaction (HFSR) secondary to sunitinib therapy.
Susan L Boone; Gayle Jameson; Daniel Von Hoff; Mario E Lacouture
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-08
Journal Detail:
Title:  Investigational new drugs     Volume:  27     ISSN:  1573-0646     ISO Abbreviation:  Invest New Drugs     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-06-25     Completed Date:  2009-09-30     Revised Date:  2009-10-05    
Medline Journal Info:
Nlm Unique ID:  8309330     Medline TA:  Invest New Drugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-90     Citation Subset:  IM    
Department of Dermatology, Northwestern University's Feinberg School of Medicine, Chicago, IL 60611, USA.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Cellular Phone*
Colorectal Neoplasms / drug therapy
Drug Eruptions / etiology
Foot Dermatoses / etiology
Hand Dermatoses / etiology
Indoles / adverse effects*
Middle Aged
Pyrroles / adverse effects*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Indoles; 0/Pyrroles; 0/sunitinib
Erratum In:
Invest New Drugs. 2009 Aug;27(4):391

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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