| Black fly salivary gland extract inhibits proliferation and induces apoptosis in murine splenocytes. | |
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MedLine Citation:
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PMID: 20398228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Black flies are known to be vectors of pathogens including Onchocerca volvulus, which causes human onchocerciasis, and Vesicular Stomatitis Virus. Their salivary secretion has been shown to contain a complex cocktail of anti-haemostatic factors and immunomodulatory activities, which may contribute to efficient transmission of the pathogens. Black fly salivary gland extract (SGE) inhibits mitogen-stimulated mouse splenocyte proliferation, including proliferation of both CD4(+) and CD8(+) T cells. The factor responsible for the inhibition was determined to be a protein (or protein complex) of a size larger than 50 kDa. Moreover, exposure to SGE results in activation of caspase 3 and characteristic morphological changes in CD4(+) and CD8(+) T cells, suggesting that induction of apoptosis could, at least in part, be responsible for this inhibition. |
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Authors:
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H Tsujimoto; E W Gray; D E Champagne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Parasite immunology Volume: 32 ISSN: 1365-3024 ISO Abbreviation: Parasite Immunol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910948 Medline TA: Parasite Immunol Country: England |
Other Details:
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Languages: eng Pagination: 275-84 Citation Subset: IM |
Affiliation:
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Department of Entomology, University of Georgia, Athens, GA 30602, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* CD4-Positive T-Lymphocytes / drug effects CD8-Positive T-Lymphocytes / drug effects Caspase 3 / metabolism Cell Proliferation / drug effects Female Leukocytes, Mononuclear / drug effects* Mice Mice, Inbred BALB C Molecular Weight Oxazines / metabolism Salivary Glands / chemistry* Salivary Proteins and Peptides / chemistry, isolation & purification, toxicity* Simuliidae / pathogenicity* Staining and Labeling / methods Xanthenes / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Oxazines; 0/Salivary Proteins and Peptides; 0/Xanthenes; 550-82-3/resazurin; EC 3.4.22.-/Caspase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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