Document Detail

The black box illuminated: signals and signaling.
MedLine Citation:
PMID:  22170487     Owner:  NLM     Status:  MEDLINE    
Unraveling the signaling pathways that transmit information from the cell surface to the nucleus has been a major accomplishment of modern cell and molecular biology. The benefit to humans is seen in the multitude of new therapeutics based on the illumination of these pathways. Although considerable insight has been gained in understanding homeostatic and pathological signaling in the epidermis and other skin compartments, the translation into therapy has been lacking. This review will outline advances made in understanding fundamental signaling in several of the most prominent pathways that control cutaneous development, cell-fate decisions, and keratinocyte growth and differentiation with the anticipation that this insight will contribute to new treatments for troubling skin diseases.
Francesca Mascia; Mitchell Denning; Raphael Kopan; Stuart H Yuspa
Related Documents :
19508387 - Inhibition of igf-ir tyrosine kinase induces apoptosis and cell cycle arrest in imatini...
7687577 - The influence of growth factors on turkey embryonic myoblasts and satellite cells in vi...
21146607 - Functional expression in insect cells of glycosylphosphatidylinositol-linked alkaline p...
20019837 - Co-overexpression of met and hepatocyte growth factor promotes systemic metastasis in n...
489787 - Cell death of motoneurons in the chick embryo spinal cord. iv. evidence that a function...
71307 - Synthesis and secretion of alpha-2-macroglobulin by cultured adherent lung cells. compa...
Publication Detail:
Type:  Journal Article; Review     Date:  2011-12-15
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  132     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-04-10     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  811-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Keratinocytes / metabolism,  pathology
Signal Transduction / physiology*
Skin / cytology*,  metabolism*
Skin Diseases / metabolism*,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sun Exposure: What Molecular Photodermatology Tells Us About Its Good and Bad Sides.
Next Document:  Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differe...