Document Detail


The black box illuminated: signals and signaling.
MedLine Citation:
PMID:  22170487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Unraveling the signaling pathways that transmit information from the cell surface to the nucleus has been a major accomplishment of modern cell and molecular biology. The benefit to humans is seen in the multitude of new therapeutics based on the illumination of these pathways. Although considerable insight has been gained in understanding homeostatic and pathological signaling in the epidermis and other skin compartments, the translation into therapy has been lacking. This review will outline advances made in understanding fundamental signaling in several of the most prominent pathways that control cutaneous development, cell-fate decisions, and keratinocyte growth and differentiation with the anticipation that this insight will contribute to new treatments for troubling skin diseases.
Authors:
Francesca Mascia; Mitchell Denning; Raphael Kopan; Stuart H Yuspa
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-12-15
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  132     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-04-10     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  811-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Humans
Keratinocytes / metabolism,  pathology
Signal Transduction / physiology*
Skin / cytology*,  metabolism*
Skin Diseases / metabolism*,  pathology*

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