Document Detail

Biventricular systolic function and mass studied with MR imaging in children with pulmonary regurgitation after repair for tetralogy of Fallot.
MedLine Citation:
PMID:  8816534     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study biventricular systolic function and mass of the heart in young patients with residual pulmonary regurgitation who had undergone surgical correction of tetralogy of Fallot. MATERIALS AND METHODS: Transverse gradient-echo magnetic resonance (MR) images covering both ventricles were obtained in 19 patients who had undergone corrective surgery for tetralogy of Fallot at the age of 1.5 years +/- 1 and in 12 age-matched control subjects. In addition, MR velocity maps of the pulmonary artery were obtained. Biventricular volumes, ejection fraction and myocardial mass, and pulmonary flow volumes were measured. Exercise tests were performed in 17 patients. RESULTS: The right ventricular ejection fraction was lower (P < .001) and the right ventricular mass was higher (P < .0005) in patients than in control subjects; the left ventricular ejection fraction was lower (P < .0005) in patients and correlated statistically significantly with pulmonary regurgitation (r = -.68; P < .005). Exercise performance inversely correlated with pulmonary regurgitation (tau = -0.5; P = .01). CONCLUSION: In children who undergo early surgical repair of tetralogy of Fallot, residual pulmonary regurgitation correlates with biventricular systolic dysfunction and diminished exercise capacity. Despite successful surgical correction, right ventricular hypertrophy may persist.
R A Niezen; W A Helbing; E E van der Wall; R J van der Geest; S A Rebergen; A de Roos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  201     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-10-28     Completed Date:  1996-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-40     Citation Subset:  AIM; IM    
Department of Diagnostic Radiology and Nuclear Medicine, Leiden University Hospital, The Netherlands.
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MeSH Terms
Case-Control Studies
Echocardiography, Doppler
Exercise Test
Hypertrophy, Right Ventricular / diagnosis*,  physiopathology
Magnetic Resonance Imaging*
Postoperative Complications / diagnosis*,  physiopathology
Pulmonary Artery / physiopathology
Pulmonary Valve Insufficiency / diagnosis*,  physiopathology
Stroke Volume / physiology
Tetralogy of Fallot / surgery*
Ventricular Function / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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