Document Detail

Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease.
MedLine Citation:
PMID:  16221225     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Left ventricular diastolic dysfunction has been shown in patients with autosomal-dominant polycystic kidney disease (ADPKD). However, there is no study evaluating right ventricular functions in these patients. METHODS: In the present study, diastolic functions of both ventricles in normotensive and hypertensive ADPKD patients with well-preserved renal function were investigated. Fifteen hypertensive and 16 normotensive patients with ADPKD with well-preserved renal function, 16 patients with essential hypertension, and 24 healthy subjects were included in the study. Conventional left and right ventricular echocardiographic measurements were performed in all subjects. Left and right ventricular functions were investigated both by myocardial performance index (MPI) [calculated by dividing the sum of isovolumic contraction time and isovolumic relaxation time (IVRT) by ejection time] and by tissue Doppler imaging (TDI). RESULTS: Left ventricular deceleration time and IVRT were significantly prolonged in hypertensive patients with ADPKD compared with patients with essential hypertension and even in normotensive patients with ADPKD compared with healthy subjects. Left and right MPIs were significantly higher in patients with ADPKD compared with healthy subjects, showing systolic and diastolic dysfunction. Moreover, by using TDI, the peak early diastolic mitral annular velocity (Em) to peak late diastolic mitral annular velocity (Am) ratio and the peak early diastolic tricuspid annular velocity (Et) to peak late diastolic tricuspid annular velocity (At) ratio were decreased in patients with ADPKD, suggesting biventricular diastolic dysfunction. CONCLUSION: Both hypertensive and normotensive patients with ADPKD show significant biventricular diastolic dysfunction, suggesting cardiac involvement very early in the course of ADPKD.
Huseyin Oflaz; Sabahat Alisir; Banu Buyukaydin; Orhan Kocaman; Faruk Turgut; Sule Namli; Burak Pamukcu; Aytac Oncul; Tevfik Ecder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  68     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-13     Completed Date:  2006-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2244-9     Citation Subset:  IM    
Department of Cardiology, Istanbul School of Medicine, Istanbul University, Turkey.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Creatinine / metabolism
Hypertension, Renal / complications,  drug therapy
Middle Aged
Polycystic Kidney, Autosomal Dominant / complications*
Ventricular Dysfunction, Left / etiology*,  ultrasonography
Ventricular Dysfunction, Right / etiology*,  ultrasonography
Reg. No./Substance:
0/Antihypertensive Agents; 60-27-5/Creatinine

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