| Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease. | |
| | |
MedLine Citation:
|
PMID: 16221225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Left ventricular diastolic dysfunction has been shown in patients with autosomal-dominant polycystic kidney disease (ADPKD). However, there is no study evaluating right ventricular functions in these patients. METHODS: In the present study, diastolic functions of both ventricles in normotensive and hypertensive ADPKD patients with well-preserved renal function were investigated. Fifteen hypertensive and 16 normotensive patients with ADPKD with well-preserved renal function, 16 patients with essential hypertension, and 24 healthy subjects were included in the study. Conventional left and right ventricular echocardiographic measurements were performed in all subjects. Left and right ventricular functions were investigated both by myocardial performance index (MPI) [calculated by dividing the sum of isovolumic contraction time and isovolumic relaxation time (IVRT) by ejection time] and by tissue Doppler imaging (TDI). RESULTS: Left ventricular deceleration time and IVRT were significantly prolonged in hypertensive patients with ADPKD compared with patients with essential hypertension and even in normotensive patients with ADPKD compared with healthy subjects. Left and right MPIs were significantly higher in patients with ADPKD compared with healthy subjects, showing systolic and diastolic dysfunction. Moreover, by using TDI, the peak early diastolic mitral annular velocity (Em) to peak late diastolic mitral annular velocity (Am) ratio and the peak early diastolic tricuspid annular velocity (Et) to peak late diastolic tricuspid annular velocity (At) ratio were decreased in patients with ADPKD, suggesting biventricular diastolic dysfunction. CONCLUSION: Both hypertensive and normotensive patients with ADPKD show significant biventricular diastolic dysfunction, suggesting cardiac involvement very early in the course of ADPKD. |
| | |
Authors:
|
Huseyin Oflaz; Sabahat Alisir; Banu Buyukaydin; Orhan Kocaman; Faruk Turgut; Sule Namli; Burak Pamukcu; Aytac Oncul; Tevfik Ecder |
Related Documents
:
|
9657405 - Evaluation of tricuspid regurgitation severity: echocardiographic and clinical correlat... 19690935 - Use of phase analysis of gated spect perfusion imaging to quantify dyssynchrony in pati... 19269825 - Chronic subdural haematomas are more common on the left than on the right. 18057055 - Left ventricular diastolic dysfunction in idiopathic pulmonary fibrosis: a tissue doppl... 20332705 - Patients affected by vitiligo and autoimmune diseases do not show antibodies interferin... 10516735 - Qtc dispersion and complex ventricular arrhythmias in untreated newly presenting hypert... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Kidney international Volume: 68 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 2005 Nov |
Date Detail:
|
Created Date: 2005-10-13 Completed Date: 2006-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
|
Languages: eng Pagination: 2244-9 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Istanbul School of Medicine, Istanbul University, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antihypertensive Agents / therapeutic use Creatinine / metabolism Diastole* Female Humans Hypertension, Renal / complications, drug therapy Male Middle Aged Polycystic Kidney, Autosomal Dominant / complications* Systole Ventricular Dysfunction, Left / etiology*, ultrasonography Ventricular Dysfunction, Right / etiology*, ultrasonography |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: ACE I/D polymorphism is associated with mortality in a cohort study of patients starting with dialys...
Next Document: Nephrotoxicity of low-osmolality versus iso-osmolality contrast agents: impact of N-acetylcysteine.