Document Detail

Bivariate and Multivariate Analyses of the Influence of Blood Variables of Patients Submitted to Roux-en-Y Gastric Bypass on the Stability of Erythrocyte Membrane against the Chaotropic Action of Ethanol.
MedLine Citation:
PMID:  23344659     Owner:  NLM     Status:  Publisher    
The stability of the erythrocyte membrane, which is essential for the maintenance of cell functions, occurs in a critical region of fluidity, which depends largely on its composition and the composition and characteristics of the medium. As the composition of the erythrocyte membrane is influenced by several blood variables, the stability of the erythrocyte membrane must have relations with them. The present study aimed to evaluate, by bivariate and multivariate statistical analyses, the correlations and causal relationships between hematologic and biochemical variables and the stability of the erythrocyte membrane against the chaotropic action of ethanol. The validity of this type of analysis depends on the homogeneity of the population and on the variability of the studied parameters, conditions that can be filled by patients who undergo bariatric surgery by the technique of Roux-en-Y gastric bypass since they will suffer feeding restrictions that have great impact on their blood composition. Pathway analysis revealed that an increase in hemoglobin leads to decreased stability of the cell, probably through a process mediated by an increase in mean corpuscular volume. Furthermore, an increase in the mean corpuscular hemoglobin (MCH) leads to an increase in erythrocyte membrane stability, probably because higher values of MCH are associated with smaller quantities of red blood cells and a larger contact area between the cell membrane and ethanol present in the medium.
Leticia Ramos de Arvelos; Vanessa Custódio Afonso Rocha; Gabriela Pereira Felix; Cleine Chagas da Cunha; Morun Bernardino Neto; Mario da Silva Garrote Filho; Conceição de Fátima Pinheiro; Elmiro Santos Resende; Nilson Penha-Silva
Related Documents :
23882789 - Quaternized poly(styrene ethylene butylene poly styrene)/multiwalled carbon nanotube co...
22127159 - Flight activity and dispersal of the cabbage seedpod weevil (coleoptera: curculionidae)...
25479509 - Contiguous 3d and 4f magnetism: strongly correlated 3d electrons in ybfe_{2}al_{10}.
23214889 - Tension of red blood cell membrane in simple shear flow.
20206009 - 8-quinolineboronic acid as a potential phosphorescent molecular switch for the determin...
25246099 - On the influence of column temperature on the isothermal retention indices of structura...
2334729 - Hydrolytic action of phospholipase a2 in monolayers in the phase transition region: dir...
884589 - Effects of acetylcholine on potassium-induced changes of water and sodium uptakes in ce...
8504069 - Thermodynamic characterization of the structural stability of the coiled-coil region of...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  The Journal of membrane biology     Volume:  -     ISSN:  1432-1424     ISO Abbreviation:  J. Membr. Biol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0211301     Medline TA:  J Membr Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia, Av. Pará, 1720, Uberlândia, MG, 38400-902, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Chromosome painting of Z and W sex chromosomes in Characidium (Characiformes, Crenuchidae).
Next Document:  Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model.