Document Detail

Bivalirudin versus unfractionated heparin in patients undergoing percutaneous coronary intervention after acute myocardial infarction.
MedLine Citation:
PMID:  16945819     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Bivalirudin is replacing heparin as the anticoagulant agent of choice for elective percutaneous coronary intervention (PCI). This study aimed to assess the safety and clinical outcomes of bivalirudin versus unfractionated heparin (UFH) in patients undergoing PCI for acute myocardial infarction (AMI). METHODS: A cohort of 672 consecutive patients presenting with AMI without prior thrombolytic therapy were treated with either bivalirudin (216 patients) or UFH (456 patients). Platelet glycoprotein IIb/IIIa inhibitors were administered at the operator's discretion. The in-hospital, 30-day, and 6-month outcomes of the two groups were compared. RESULTS: Baseline clinical and angiographic characteristics were similar between the groups. In-hospital complications were similar, although there was a trend of a less major hematocrit drop in the bivalirudin group (0.9% vs. 3.1%, P=.09). All clinical outcomes were similar between the groups at 30-day and 6-month follow-ups. There was no statistical significance for acute thrombosis and subacute thrombosis between the groups, and there was no late thrombosis from either group. The event-free survival rate was similar between the groups (P=.41). CONCLUSION: The use of bivalirudin in patients undergoing PCI after AMI is safe and feasible. Bivalirudin should be considered as an alternative anticoagulant agent during PCI to treat patients presenting with AMI.
William W Chu; Pramod K Kuchulakanti; Betty Wang; Rebecca Torguson; Leonardo C Clavijo; Augusto D Pichard; William O Suddath; Lowell F Satler; Kenneth M Kent; Ron Waksman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cardiovascular revascularization medicine : including molecular interventions     Volume:  7     ISSN:  1553-8389     ISO Abbreviation:  -     Publication Date:    2006 Jul-Sep
Date Detail:
Created Date:  2006-09-01     Completed Date:  2007-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101238551     Medline TA:  Cardiovasc Revasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-5     Citation Subset:  IM    
Division of Cardiology, Washington Hospital Center, Washington, DC, USA.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary* / adverse effects
Anticoagulants / therapeutic use*
Coronary Angiography
Disease-Free Survival
Follow-Up Studies
Heparin / analogs & derivatives*,  therapeutic use*
Middle Aged
Myocardial Infarction / radiography,  therapy*
Peptide Fragments / therapeutic use*
Platelet Aggregation Inhibitors / therapeutic use
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors,  therapeutic use
Postoperative Complications / etiology,  radiography
Recombinant Proteins / therapeutic use
Research Design
Ticlopidine / analogs & derivatives,  therapeutic use
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Anticoagulants; 0/Hirudins; 0/Peptide Fragments; 0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 0/Recombinant Proteins; 128270-60-0/bivalirudin; 55142-85-3/Ticlopidine; 9005-49-6/Heparin; 90055-48-4/clopidogrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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