| Bivalirudin: a review of the pharmacology and clinical application. | |
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MedLine Citation:
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PMID: 21108549 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Among the current agents in the class of direct thrombin inhibitors, bivalirudin (Angiomax(®), The Medicines Company, NJ, USA) has seen increased use in cardiovascular medicine over the past decade through its primary indication as an anticoagulant used during percutaneous coronary interventions. Bivalirudin has been further investigated and used as the anticoagulation strategy in the setting of cardiac and endovascular surgical procedures and is frequently utilized in the management of patients with heparin-induced thrombocytopenia. In comparison with heparin, bivalirudin exhibits a low immunogenic profile and provides similar or reduced major bleeding rates as well as a predictable degree of anticoagulation that is dose related. Bivalirudin primarily undergoes dual elimination via proteolytic cleavage and renal elimination, and requires dose adjustment in the setting of severe renal dysfunction. Given the body of supportive data, bivalirudin is likely to continue to figure prominently as a reliable and efficient anticoagulation strategy. Additional agents in the class of direct thrombin inhibitors are under investigation and may find increasing clinical use. |
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Authors:
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David A Van De Car; Sunil V Rao; E Magnus Ohman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 8 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 1673-81 Citation Subset: IM |
Affiliation:
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Duke University Medical Center, Division of Cardiology, 2301 Erwin Road, Durham, NC, USA. david.vandecar@duke.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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