| Bivalirudin (Angiomax) use during intracoronary brachytherapy may predispose to acute closure. | |
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MedLine Citation:
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PMID: 12652325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe two cases of intracoronary vascular brachytherapy where bivalirudin (Angiomax), employed as an anticoagulant, led to abrupt vessel closure or threatened abrupt closure. Use of bivalirudin (Angiomax) during intracoronary brachytherapy may predispose to the formation of intracoronary thrombus, related to the reversible binding kinetics of the bivalirudin to thrombin, and resulting in recovery of thrombin functional activity during periods of prolonged stasis that occur during intracoronary brachytherapy. Intracoronary abciximab administration may be a useful strategy in resolving the acute closure, since abciximab administered early during the formation of thrombus has been shown to facilitate clot lysis. |
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Authors:
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Sanjiv Sharma; Brijesh Bhambi; William Nyitray; Kirit Desai; Dean L Davis; Geetanjali Sharma; Pankaj Shukla; Carla File; Tetsuo Ishimori |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology and therapeutics Volume: 8 ISSN: 1074-2484 ISO Abbreviation: J. Cardiovasc. Pharmacol. Ther. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-24 Completed Date: 2003-07-15 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9602617 Medline TA: J Cardiovasc Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 9-15 Citation Subset: IM |
Affiliation:
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Central Cardiology Medical Clinic, Bakersfield, CA 93301, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Antibodies, Monoclonal / therapeutic use Brachytherapy* Coronary Angiography Coronary Restenosis / drug therapy, etiology*, prevention & control Coronary Vessels / physiopathology* Female Hirudin Therapy / adverse effects* Hirudins / adverse effects*, analogs & derivatives* Humans Immunoglobulin Fab Fragments / therapeutic use Injections Male Middle Aged Peptide Fragments / adverse effects*, therapeutic use Recombinant Proteins / adverse effects*, therapeutic use Thrombin / antagonists & inhibitors* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Hirudins; 0/Immunoglobulin Fab Fragments; 0/Peptide Fragments; 0/Recombinant Proteins; 128270-60-0/bivalirudin; 143653-53-6/abciximab; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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