| Biting suppresses stress-induced expression of corticotropin-releasing factor (CRF) in the rat hypothalamus. | |
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MedLine Citation:
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PMID: 14742649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Corticotropin-releasing factor (CRF) expressed in the hypothalamus plays an important role in mediating behavioral responses to stressors. Restraining the body of an animal has been shown to activate and induce an enhanced expression of CRF in paraventricular neurons of the rat hypothalamus. Since aggressive biting behavior is known to suppress stress-induced noradrenaline secretion in the central nervous system and the formation of gastric ulcers, we investigated the effect of biting on restraint-induced CRF expression in the rat hypothalamus. The number of CRF-expressing neurons in the paraventricular nucleus increased significantly after short time restraint (30 or 60 min) followed by a 180-minute post-restraint period. Biting of a wooden stick during the restraint stress significantly suppressed the restraint-induced enhancement of CRF expression in the paraventricular nucleus. These observations suggest a possible anti-stress effect of biting and an important role of para-functional masticatory activity in coping with stressful events. |
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Authors:
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N Hori; N Yuyama; K Tamura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of dental research Volume: 83 ISSN: 0022-0345 ISO Abbreviation: J. Dent. Res. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-01-26 Completed Date: 2004-08-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: United States |
Other Details:
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Languages: eng Pagination: 124-8 Citation Subset: D; IM |
Affiliation:
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Departments of Prosthetics, Kanagawa Dental College, Kanagawa, Japan. horin@kdcnet.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Psychological
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physiology Aggression / physiology Animals Behavior, Animal / physiology Bites and Stings / metabolism* Corticotropin-Releasing Hormone / analysis* Dental Occlusion, Traumatic / metabolism Hypothalamus / pathology, secretion* Male Neurons / metabolism, ultrastructure Paraventricular Hypothalamic Nucleus / metabolism, pathology Rats Rats, Sprague-Dawley Restraint, Physical Stress, Physiological / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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