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Bitemporal Intractable Epilepsy: Could It Be Surgically Treatable?.
MedLine Citation:
PMID:  23364510     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: The goal of this study is to retrieve the attention to the treatment opportunities for this cohort of intractable bitemporal epilepsy patients who in most cases are not considered optimal candidates for surgery. Objectives: The purpose of this study is to demonstrate that electrophysiologically guided precise surgeries on both temporal lobes can have a beneficial effect on seizures without additional cognitive decline. Methods: Twenty-one intractable bitemporal epilepsy patients [13 men, 8 women, mean age 21 years (range 6-43), mean duration of illness 17 years (range 3-31), frequency of seizures 6-55 per month] underwent stereotactic cryosurgery on both temporal lobes guided by chronic and intraoperative depth electrode studies. Results: Class I ('free of disabling seizures') outcome was achieved for 11/21 (52%), class II ('rare seizures') for 6/21 (29%), and class IV ('no worthwhile improvement') for 4/21 (19%) patients. No worsening of seizure or clinically significant cognitive or memory impairments were observed in this cohort of patients (follow-up 5-10 years). Conclusions: The minimally invasive precise surgeries on both temporal lobes confined to the removal/lesion of just the brain tissue that exhibited epileptic activity can have a beneficial effect on seizure frequency and severity without additional devastating declines in intelligence, learning and memory.
Authors:
Sozari A Chkhenkeli; Miron Sramka; Tamas N Rakviashvili; George S Lortkipanidze; George E Magalashvili; Eteri Sh Bregvadze; Alexander Otarashvili; Tamar Sh Gagoshidze
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Stereotactic and functional neurosurgery     Volume:  91     ISSN:  1423-0372     ISO Abbreviation:  Stereotact Funct Neurosurg     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902881     Medline TA:  Stereotact Funct Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  104-112     Citation Subset:  -    
Copyright Information:
Copyright © 2013 S. Karger AG, Basel.
Affiliation:
Department of Functional Neurosurgery, Epilepsy Surgery Center, The Saradzhishvili Institute of Clinical and Experimental Neurology, Tbilisi, Georgia.
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