Document Detail

Bistable dynamics of cardiac cell models coupled by dynamic gap junctions linked to cardiac memory.
MedLine Citation:
PMID:  20012545     Owner:  NLM     Status:  MEDLINE    
In an earlier study, we suggested that adaptive gap junctions (GJs) might be a basis of cardiac memory, a phenomenon which refers to persistent electrophysiological response of the heart to external pacing. Later, it was also shown that the proposed mechanism of adaptation of GJs is consistent with known electrophysiology of GJs. In the present article, we show that a pair of cardiac cell models coupled by dynamic, voltage-sensitive GJs exhibits bistable behavior under certain conditions. Three kinds of cell pairs are considered: (1) a Noble-Noble cell pair that represents adjacent cells in Purkinje network, (2) a pair of DiFranceso-Noble cells that represents adjacent SA nodal cells, and (3) a model of Noble cell coupled to Luo-Rudy cell model, which represents an interacting pair of a Purkinje fiber and a ventricular myocyte. Bistability is demonstrated in all the three cases. We suggest that this bistability might be an underlying factor behind cardiac memory. Focused analysis of a pair of Noble cell models showed that bistability is obtained only when the properties of GJs "match" with the properties of the pair of cells that is coupled by the GJs. This novel notion of match between GJs and cardiac cell types might give an insight into specialized distributions of various connexin proteins in cardiac tissue.
Gairik Sachdeva; Kanakapriya Kalyanasundaram; J Krishnan; V S Chakravarthy
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Publication Detail:
Type:  Journal Article     Date:  2009-12-11
Journal Detail:
Title:  Biological cybernetics     Volume:  102     ISSN:  1432-0770     ISO Abbreviation:  Biol Cybern     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502533     Medline TA:  Biol Cybern     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  109-21     Citation Subset:  IM    
Department of Biotechnology, Indian Institute of Technology, Chennai, India.
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MeSH Terms
Adaptation, Physiological / physiology*
Cell Communication / physiology
Gap Junctions / physiology*
Heart / physiology*
Heart Conduction System / cytology,  physiology*
Models, Neurological*
Muscle Cells / cytology,  physiology
Myocardium / cytology*

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