| Bistability in biochemical signaling models. | |
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MedLine Citation:
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PMID: 21954291 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This Teaching Resource provides lecture notes, slides, and a student assignment for a two-part lecture on the principles underlying bistability in biochemical signaling networks, which are illustrated with examples from the literature. The lectures cover analog, or graded, versus digital, all-or-none, responses in cells, with examples from different types of biological processes requiring each. Rate-balance plots are introduced as a method for determining whether generic one-variable systems exhibit one or several stable steady states. Bifurcation diagrams are presented as a more general method for detecting the presence of bistability in biochemical signaling networks. The examples include an artificial toggle switch, the lac operon in bacteria, and the mitogen-activated protein kinase cascade in both Xenopus oocytes and mammalian cells. The second part of the lecture links the concepts of bistability more closely to the mathematical tools provided by dynamical systems analysis. The examples from the first part of the lecture are analyzed with phase-plane techniques and bifurcation analysis, using the scientific programming language MATLAB. Using these programs as a template, the assignment requires the students to implement a model from the literature and analyze the stability of this model's steady states. |
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Authors:
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Eric A Sobie |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-09-20 |
Journal Detail:
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Title: Science signaling Volume: 4 ISSN: 1937-9145 ISO Abbreviation: Sci Signal Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-28 Completed Date: 2012-01-10 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 101465400 Medline TA: Sci Signal Country: United States |
Other Details:
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Languages: eng Pagination: tr10 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA. eric.sobie@mssm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biochemistry
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education*,
methods Computational Biology / education*, methods Kinetics Lac Operon Mitogen-Activated Protein Kinases / metabolism Models, Biological* Signal Transduction / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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P50 GM071558-04/GM/NIGMS NIH HHS; PS0GM071558/GM/NIGMS NIH HHS; T32GM062754/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.11.24/Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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