Document Detail

Bisphosphonates and oral pathology II. Osteonecrosis of the jaws: review of the literature before 2005.
MedLine Citation:
PMID:  17072246     Owner:  NLM     Status:  MEDLINE    
Bisphosphonates are bone-turnover modulating drugs which are used in the management of a number of bone diseases ranging from osteoporosis to neoplasic pathology-associated osteolysis. In the last years a number of cases of osteonecrosis of the jaws associated with these drugs have been reported. In this review we analyze the cases published in the literature indexed from 2003 to December 2005. During this period 246 cases were reported, being more frequently associated with women in the sixth decade of life. More frequently associated bisphosphonates were the nitrogenated bisphosphonates (pamidronate, zolendronic acid) and the most common oral antecedent was a dental extraction. Nevertheless more than 25% of the cases were spontaneous. The most frequent site was the mandible and most of the cases presented clinical evidence of bone exposure and pain. Different treatments have been proposed with different antibiotic therapies with or without surgery, showing in general terms an uncertain prognosis with low healing rates.
Ruth Estefanía Fresco; Ruth Ponte Fernández; José Manuel Aguirre Urizar
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-11-01
Journal Detail:
Title:  Medicina oral, patología oral y cirugía bucal     Volume:  11     ISSN:  1698-6946     ISO Abbreviation:  Med Oral Patol Oral Cir Bucal     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-01-25     Revised Date:  2009-12-11    
Medline Journal Info:
Nlm Unique ID:  101231694     Medline TA:  Med Oral Patol Oral Cir Bucal     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  E456-61     Citation Subset:  D; IM    
Medicina Bucal, Departamento de Estomatología, Unidad de Patología Oral y Maxilofacial, Servicio Clínica Odontológica, Universidad del País Vasco EHU.
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MeSH Terms
Aged, 80 and over
Diphosphonates / adverse effects*
Jaw Diseases / chemically induced*
Middle Aged
Osteonecrosis / chemically induced*
Reg. No./Substance:

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