Document Detail

Bisphosphonate-related osteonecrosis of the jaw presenting as a cutaneous dental sinus tract: a case report and review of the literature.
MedLine Citation:
PMID:  20153079     Owner:  NLM     Status:  MEDLINE    
Bisphosphonates are endogenous pyrophosphate analogs that work to inhibit osteoclast activity. They are commonly used in the treatment of patients with bone related diseases, such as solid tumor metastasis and osteoporosis. One of the infrequent but not rare side effects, especially with high doses of bisphosphonates, is osteonecrosis of the jaw. Although predominantly recognized by dentists because of the bony and intraoral manifestations of the disease, it may also present on the skin. We present a case of osteonecrosis of the jaw resembling two flesh-colored papules associated with dental sinus tracts to highlight the clinical manifestations that dermatologists may encounter, and review the literature on this rare but morbid condition.
Sam V Truong; Linda C Chang; Timothy G Berger
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-02-11
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  62     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  672-6     Citation Subset:  IM    
Copyright Information:
Copyright 2008 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Department of Dermatology, University of California-San Francisco, San Francisco, California, USA.
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MeSH Terms
Aged, 80 and over
Cutaneous Fistula / etiology*
Diphosphonates / adverse effects*
Fistula / etiology*
Jaw Diseases / chemically induced*,  complications*,  pathology
Osteonecrosis / chemically induced*,  complications*
Periapical Diseases / etiology*
Reg. No./Substance:

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