| Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism. | |
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MedLine Citation:
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PMID: 16622740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization. Preoperative administration of bisphosphonates, potent inhibitors of osteoclast activity, may prevent postoperative hypocalcemia after parathyroidectomy. We retrospectively reviewed medical records to investigate the effect of bisphosphonate pretreatment on serum calcium level changes after parathyroidectomy. Twenty-three patients with a diagnosis of primary hyperparathyroidism underwent parathyroidectomy between April 1997 and August 2002. Clinical and laboratory data were collected before and after the operation. These patients were divided into two groups; those showing hungry bone syndrome (n = 9) and those not (n = 14). None of the 9 patients with hungry bone syndrome had received bisphosphonate pretreatment. Of the 14 patients without hungry bone syndrome, 6 had received bisphosphonate pretreatment (P < 0.05). Furthermore, preoperative calcium concentration was not related to the occurrence of hypo-calcemia in those without bisphosphonate pretreatment. In conclusion, administration of bisphosphonates in primary hyperparathyroidism can prevent the occurrence of hungry bone syndrome after parathyroidectomy. |
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Authors:
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I-Te Lee; Wayne Huey-Herng Sheu; Shih-Te Tu; Shi-Wen Kuo; Dee Pei |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of bone and mineral metabolism Volume: 24 ISSN: 0914-8779 ISO Abbreviation: J. Bone Miner. Metab. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-04-19 Completed Date: 2006-06-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9436705 Medline TA: J Bone Miner Metab Country: Japan |
Other Details:
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Languages: eng Pagination: 255-8 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, No. 160, Sec 3, Chung Kang Road, Taichung 407, Taiwan, ROC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Calcium / blood Clodronic Acid / therapeutic use Diphosphonates / therapeutic use* Female Humans Hyperparathyroidism, Primary / drug therapy*, surgery* Hypocalcemia / drug therapy*, etiology Male Middle Aged Parathyroidectomy / adverse effects* Preoperative Care Retrospective Studies Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Diphosphonates; 10596-23-3/Clodronic Acid; 40391-99-9/pamidronate; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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