| Bisphosphonate osteonecrosis of the jaw: A historical and contemporary review. | |
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MedLine Citation:
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PMID: 22233554 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The use of bisphosphonate drugs has been popularised in the late 20th century for the management of many conditions associated with abnormalities of bone turnover, particularly metastatic and haematogenous malignancy and osteopenia. The increase in indications for the use of bisphosphonates was supported by what was thought to be a very good safety profile. However in 2003 cases of osteonecrosis related to the use of bisphosphonates were first described. The pathogenesis, and with this the explanation of why it only appears to affect the maxillofacial skeleton, and the best way of managing this problem remains unknown. In this review we examine the process of identification of this pathology and the development of guidelines from medical societies and professional bodies on the management of patients before commencing bisphosphonate therapy, requiring dental treatment whilst on therapy, or with a diagnosis of bisphosphonate associated osteonecrosis of the jaws. |
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Authors:
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Niall M H McLeod; Peter A Brennan; Salvatore L Ruggiero |
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Publication Detail:
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Type: Journal Article Date: 2011-10-07 |
Journal Detail:
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Title: The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Volume: 10 ISSN: 1479-666X ISO Abbreviation: Surgeon Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168329 Medline TA: Surgeon Country: Scotland |
Other Details:
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Languages: eng Pagination: 36-42 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Oral & Maxillofacial Surgery, John Radcliffe Hospital, Oxford OX3 9DU, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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