| Bisphosphonate-induced osteonecrosis of the jaw: a review of 2,400 patient cases. | |
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MedLine Citation:
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PMID: 20508948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Bisphosphonates (BPs) are bone-remodeling inhibitors that are used to manage bone metastases and osteoporosis. Osteonecrosis of the jaw, however, can occur during treatment. This complication is poorly understood and is called "bisphosphonate-induced osteonecrosis of the jaw" (BIOJ). METHODS: We performed a PubMed-based review of all of the described cases of BIOJ from January 2003 (the year of the first description) to September 2009. Issues of clinical relevance, such as the primary diagnosis and type of treatment, were evaluated for each patient case. RESULTS: We retrieved 2,408 cases, 88% of which were associated with intravenous therapy, primarily with zoledronate. Of the total number of cases, 89% were associated with the treatment of a malignant condition, particularly multiple myeloma (43% of the cases). Of all the BIOJ cases, 67% were preceded by tooth extraction and only 35% of patients were cured. CONCLUSION: Prevention is better than treatment, and the establishment of meticulous oral hygiene and surgical procedures prior to commencing BP treatment is important for preventing BIOJ. Our review summarizes the current knowledge about this severe complication. Future studies, especially basic research studies, are needed to better understand this devastating disease. |
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Authors:
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O Filleul; E Crompot; S Saussez |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-05-28 |
Journal Detail:
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Title: Journal of cancer research and clinical oncology Volume: 136 ISSN: 1432-1335 ISO Abbreviation: J. Cancer Res. Clin. Oncol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2010-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902060 Medline TA: J Cancer Res Clin Oncol Country: Germany |
Other Details:
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Languages: eng Pagination: 1117-24 Citation Subset: IM |
Affiliation:
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Faculty of Medicine and Pharmacy, Department of Anatomy and Cellular Biology, University of Mons, Pentagone 2C-Avenue du Champ de Mars, 6, B-7000, Mons, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Remodeling
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drug effects* Diphosphonates / adverse effects*, therapeutic use Female Humans Jaw Diseases / chemically induced*, pathology Male Mandibular Diseases / chemically induced, pathology, surgery Maxilla / pathology, surgery Maxillary Diseases / chemically induced, pathology, surgery Osteitis Deformans / chemically induced Osteonecrosis / chemically induced*, pathology, surgery, therapy* Retrospective Studies Sex Ratio |
| Chemical | |
Reg. No./Substance:
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0/Diphosphonates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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