Document Detail


Bisphosphonate-containing supramolecular hydrogels for topical decorporation of uranium-contaminated wounds in mice.
MedLine Citation:
PMID:  18464065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Personnel experiencing accidents that involve radionuclides or victims of potential malicious radioactive attacks may suffer injuries with wounds contaminated by radionuclides. The current treatment for contamination from uranium in external injuries is the use of saline solution to wash the wounds, which has the drawback of further spreading of the contaminants due to the flow of water. To minimize the cost of storage of contaminated liquids and to improve the efficiency of treatment, we propose the use of hydrogels as a form of decorporation agent. METHODS: Mice with uranium-contaminated wounds on their backs were treated with bisphosphonate or diethylene triamine pentaacetic acid (DTPA) containing supramolecular hydrogels. Survival rates of the treated mice and changes in the body weight of the mice were observed and compared to those of mice without hydrogel treatment. Distribution of uranium in the mice was also explored as proof of the effectiveness of the hydrogel treatment. RESULTS: The survival rate of the hydrogel-treated mice was significantly higher than that of the mice without treatment. The body weights of the hydrogel-treated mice showed significant recovery after 10 days while the body weight of mice without hydrogel treatment continuously decreased. The amount of uranyl ions in the organs (mainly concentrated in the kidney) of the hydrogel-treated mice was much smaller than that of the mice without hydrogel treatment. CONCLUSIONS: By incorporating uranium chelating agents, we developed new supramolecular hydrogels that could effectively and conveniently decorporate uranium ions from the contaminated wound sites of mice, with the highest efficacy achieved by our pamidronate-based molecular hydrogel.
Authors:
Keming Xu; Weiwei Ge; Gaolin Liang; Ling Wang; Zhimou Yang; Qigang Wang; I-Ming Hsing; Bing Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of radiation biology     Volume:  84     ISSN:  0955-3002     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-08     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  353-62     Citation Subset:  IM; S    
Affiliation:
Bioengineering Program, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong (SAR), China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diphosphonates / chemistry*
Female
Hydrogels / chemistry*
Ions
Kidney / drug effects,  metabolism
Mice
Mice, Inbred ICR
Pentetic Acid / chemistry
Radiation Injuries, Experimental / drug therapy*
Skin / metabolism,  radiation effects*
Uranium / chemistry*
Uranium Compounds / chemistry
Uranyl Nitrate / pharmacology
Wound Healing
Chemical
Reg. No./Substance:
0/Diphosphonates; 0/Hydrogels; 0/Ions; 0/Uranium Compounds; 10102-06-4/Uranyl Nitrate; 67-43-6/Pentetic Acid; 7440-61-1/Uranium

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