| Bisphosphonate-associated osteonecrosis of the jaw, with healing after teriparatide: a review of the literature and a case report. | |
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MedLine Citation:
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PMID: 20415805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper reports the case history of a patient who had bisphosphonate-associated osteonecrosis of the jaw (ONJ) in which adjunctive treatment with teriparatide was used. The patient was treated for 5 years with alendronate for osteoporosis and developed ONJ after extraction of maxillary teeth. An implant was placed at the site of the extracted teeth. The pathology report confirmed the clinical diagnosis of ONJ; treatment was changed from alendronate to teriparatide and the ONJ resolved. To our knowledge, this is the third case history reported in the literature in which teriparatide was successfully used as adjunct therapy in ONJ because it has an anabolic effect and presumed role in accelerating bone healing. ONJ is a serious but infrequent condition that has been recently associated with nitrogen-containing bisphosphonate therapy. Teriparatide may be a useful adjunctive therapy when ONJ develops. |
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Authors:
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Pongthorn Narongroeknawin; Maria I Danila; Lewis G Humphreys; Andrei Barasch; Jeffrey R Curtis |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry Volume: 30 ISSN: 1754-4505 ISO Abbreviation: Spec Care Dentist Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-15 Revised Date: 2010-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8103755 Medline TA: Spec Care Dentist Country: United States |
Other Details:
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Languages: eng Pagination: 77-82 Citation Subset: D |
Affiliation:
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Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alendronate
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adverse effects Bone Density Conservation Agents / administration & dosage, adverse effects*, therapeutic use Bone Regeneration / drug effects Dental Implants Diphosphonates / adverse effects* Follow-Up Studies Humans Injections, Subcutaneous Male Maxillary Diseases / chemically induced*, drug therapy Middle Aged Osteoarthritis / drug therapy Osteonecrosis / chemically induced*, drug therapy Osteoporosis / drug therapy Teriparatide / administration & dosage, therapeutic use* Tooth Extraction |
| Chemical | |
Reg. No./Substance:
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0/Bone Density Conservation Agents; 0/Dental Implants; 0/Diphosphonates; 52232-67-4/Teriparatide; 66376-36-1/Alendronate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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