Document Detail


Bisphosphonate-associated osteonecrosis of the jaw, with healing after teriparatide: a review of the literature and a case report.
MedLine Citation:
PMID:  20415805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper reports the case history of a patient who had bisphosphonate-associated osteonecrosis of the jaw (ONJ) in which adjunctive treatment with teriparatide was used. The patient was treated for 5 years with alendronate for osteoporosis and developed ONJ after extraction of maxillary teeth. An implant was placed at the site of the extracted teeth. The pathology report confirmed the clinical diagnosis of ONJ; treatment was changed from alendronate to teriparatide and the ONJ resolved. To our knowledge, this is the third case history reported in the literature in which teriparatide was successfully used as adjunct therapy in ONJ because it has an anabolic effect and presumed role in accelerating bone healing. ONJ is a serious but infrequent condition that has been recently associated with nitrogen-containing bisphosphonate therapy. Teriparatide may be a useful adjunctive therapy when ONJ develops.
Authors:
Pongthorn Narongroeknawin; Maria I Danila; Lewis G Humphreys; Andrei Barasch; Jeffrey R Curtis
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry     Volume:  30     ISSN:  1754-4505     ISO Abbreviation:  Spec Care Dentist     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-07-15     Revised Date:  2014-08-27    
Medline Journal Info:
Nlm Unique ID:  8103755     Medline TA:  Spec Care Dentist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  D    
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MeSH Terms
Descriptor/Qualifier:
Alendronate / adverse effects
Bone Density Conservation Agents / administration & dosage,  adverse effects*,  therapeutic use
Bone Regeneration / drug effects
Dental Implants
Diphosphonates / adverse effects*
Follow-Up Studies
Humans
Injections, Subcutaneous
Male
Maxillary Diseases / chemically induced*,  drug therapy
Middle Aged
Osteoarthritis / drug therapy
Osteonecrosis / chemically induced*,  drug therapy
Osteoporosis / drug therapy
Teriparatide / administration & dosage,  therapeutic use*
Tooth Extraction
Grant Support
ID/Acronym/Agency:
K23 AR053351/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Dental Implants; 0/Diphosphonates; 10T9CSU89I/Teriparatide; X1J18R4W8P/Alendronate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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