Document Detail

Bisphosphonate-associated osteonecrosis of the jaws and endodontic treatment: two case reports.
MedLine Citation:
PMID:  16186759     Owner:  NLM     Status:  MEDLINE    
Bisphosphonates are commonly used in the management of bone diseases, such as osteoporosis and Paget's disease, and to prevent bone complications and to treat malignant hypercalcemia in certain types of cancer. Although this class of drugs has clear evidence of medical efficacy, there are an increasing number of reports of bisphosphonate-associated osteonecrosis of the jaws that have substantial implications for the patient and for the treating dentist. This case report reviews proposed possible mechanisms of bisphosphonate-associated osteonecrosis of the jaws and describes two case reports where nonsurgical and surgical root canal treatments were precipitating factors. Recommendations for prevention and treatment of the disease follow. Thorough history taking and timely consultation with the patient's oral surgeon and oncologist are emphasized.
Aaron P Sarathy; Sidney L Bourgeois; Gary G Goodell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of endodontics     Volume:  31     ISSN:  0099-2399     ISO Abbreviation:  J Endod     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-27     Completed Date:  2006-01-04     Revised Date:  2006-06-06    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  759-63     Citation Subset:  D    
National Naval Medical Center, and Naval Postgraduate Dental School, NNMC, Bethesda, Maryland, USA.
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MeSH Terms
Alendronate / adverse effects
Bone Density Conservation Agents / adverse effects*
Diphosphonates / adverse effects*
Imidazoles / adverse effects
Jaw Diseases / chemically induced*
Osteonecrosis / chemically induced*
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Diphosphonates; 0/Imidazoles; 118072-93-8/zoledronic acid; 40391-99-9/pamidronate; 66376-36-1/Alendronate
Erratum In:
J Endod. 2005 Nov;31(11):835-6
Republished in:
J Mass Dent Soc. 2006 Spring;55(1):44-8   [PMID:  16683515 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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