Document Detail

Bisphosphonate-associated osteonecrosis of the jaw: does it occur in children?
MedLine Citation:
PMID:  18221397     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Bisphosphonate use in adult patients has been linked to osteonecrosis of the jaw (ONJ). This complication has not been systematically assessed in a paediatric population receiving bisphosphonates. OBJECTIVE: To assess our cohort of paediatric patients treated with intravenous bisphosphonate for occurrence of ONJ. DESIGN: Observational study at a tertiary children's hospital. PATIENTS: A total of 42 paediatric patients with osteoporosis who received bisphosphonate infusions for a mean of 6.5 years (SD 2.7 years) were assessed clinically and radiographically for possible ONJ. Among 42, 37 patients had received disodium pamidronate 1 mg/kg/dose at a mean cumulative dose of 19.8 mg/kg and zoledronic acid (ZA) 0.05 mg/kg/dose at a mean cumulative dose of 0.49 mg/kg; four had received ZA and one received pamidronate alone. Invasive dental treatment during bisphosphonate treatment, a known risk factor for osteonecrosis, was specifically assessed. RESULTS: In all patients assessed, including 11 who had invasive dental treatment, there were no cases of osteonecrosis. CONCLUSION: ONJ has so far not been demonstrated in this patient group.
J J Brown; L Ramalingam; M R Zacharin
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Publication Detail:
Type:  Journal Article     Date:  2008-01-21
Journal Detail:
Title:  Clinical endocrinology     Volume:  68     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-20     Completed Date:  2009-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  863-7     Citation Subset:  IM    
Monash Medical Centre, Clayton 3168, Victoria, Australia.
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MeSH Terms
Bone Density Conservation Agents / adverse effects*
Cohort Studies
Diphosphonates / adverse effects*
Imidazoles / adverse effects*
Jaw Diseases / chemically induced*
Oral Surgical Procedures / adverse effects
Osteonecrosis / chemically induced*
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Diphosphonates; 0/Imidazoles; 118072-93-8/zoledronic acid; 40391-99-9/pamidronate

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