| Bisphosphonate-associated osteonecrosis of the jaw: does it occur in children? | |
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MedLine Citation:
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PMID: 18221397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Bisphosphonate use in adult patients has been linked to osteonecrosis of the jaw (ONJ). This complication has not been systematically assessed in a paediatric population receiving bisphosphonates. OBJECTIVE: To assess our cohort of paediatric patients treated with intravenous bisphosphonate for occurrence of ONJ. DESIGN: Observational study at a tertiary children's hospital. PATIENTS: A total of 42 paediatric patients with osteoporosis who received bisphosphonate infusions for a mean of 6.5 years (SD 2.7 years) were assessed clinically and radiographically for possible ONJ. Among 42, 37 patients had received disodium pamidronate 1 mg/kg/dose at a mean cumulative dose of 19.8 mg/kg and zoledronic acid (ZA) 0.05 mg/kg/dose at a mean cumulative dose of 0.49 mg/kg; four had received ZA and one received pamidronate alone. Invasive dental treatment during bisphosphonate treatment, a known risk factor for osteonecrosis, was specifically assessed. RESULTS: In all patients assessed, including 11 who had invasive dental treatment, there were no cases of osteonecrosis. CONCLUSION: ONJ has so far not been demonstrated in this patient group. |
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Authors:
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J J Brown; L Ramalingam; M R Zacharin |
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Publication Detail:
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Type: Journal Article Date: 2008-01-21 |
Journal Detail:
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Title: Clinical endocrinology Volume: 68 ISSN: 1365-2265 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-20 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 863-7 Citation Subset: IM |
Affiliation:
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Monash Medical Centre, Clayton 3168, Victoria, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Bone Density Conservation Agents / adverse effects* Child Cohort Studies Diphosphonates / adverse effects* Humans Imidazoles / adverse effects* Jaw Diseases / chemically induced* Oral Surgical Procedures / adverse effects Osteonecrosis / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Bone Density Conservation Agents; 0/Diphosphonates; 0/Imidazoles; 118072-93-8/zoledronic acid; 40391-99-9/pamidronate |
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