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Bisphosphonate-associated orbital inflammation-a case report and review.
MedLine Citation:
PMID:  22489855     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Bisphosphonates are becoming more widespread as indications for them broaden. Several ocular side effects due to bisphosphonates have been described, among the most potentially serious of which is orbital inflammation. Thirteen case reports of this side effect exist in the literature, with an additional case reported here. The most common presenting signs are lid edema, conjunctival hyperemia, and chemosis, while common symptomatology includes pain, diplopia, and blurry vision. A concomitant anterior uveitis is present in 30% of cases, and some degree of bilaterality is also seen in 30% of cases. There are two reported instances of profound visual loss, highlighting the importance of prompt recognition and treatment of this entity. Despite a paucity of rechallenge data, available reports suggest that development of orbital inflammation does not necessarily exclude patients from future bisphosphonate use.
Authors:
Jared D Peterson; Edward H Bedrossian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Orbit (Amsterdam, Netherlands)     Volume:  31     ISSN:  1744-5108     ISO Abbreviation:  Orbit     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301221     Medline TA:  Orbit     Country:  England    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Affiliation:
Oculoplastic and Orbital Surgery Service, Wills Eye Institute , Philadelphia, PA.
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