Document Detail


Bisphosphonate Use and Prevalence of Valvular and Vascular Calcification in Women MESA (The Multi-Ethnic Study of Atherosclerosis).
MedLine Citation:
PMID:  21070928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: the aim of this study was to determine whether nitrogen-containing bisphosphonate (NCBP) therapy is associated with the prevalence of cardiovascular calcification.
BACKGROUND: cardiovascular calcification correlates with atherosclerotic disease burden. Experimental data suggest that NCBP might limit cardiovascular calcification, which has implications for disease prevention.
METHODS: the relationship of NCBP use to the prevalence of aortic valve, aortic valve ring, mitral annulus, thoracic aorta, and coronary artery calcification (AVC, AVRC, MAC, TAC, and CAC, respectively) detected by computed tomography was assessed in 3,710 women within the MESA (Multi-Ethnic Study of Atherosclerosis) with regression modeling.
RESULTS: Analyses were age-stratified, because of a significant interaction between age and NCBP use (interaction p values: AVC p < 0.0001; AVRC p < 0.0001; MAC p = 0.002; TAC p < 0.0001; CAC p = 0.046). After adjusting for age; body mass index; demographic data; diabetes; smoking; blood pressure; cholesterol levels; and statin, hormone replacement, and renin-angiotensin inhibitor therapy, NCBP use was associated with a lower prevalence of cardiovascular calcification in women ≥ 65 years of age (prevalence ratio: AVC 0.68 [95% confidence interval (CI): 0.41 to 1.13]; AVRC 0.65 [95% CI: 0.51 to 0.84]; MAC 0.54 [95% CI: 0.33 to 0.93]; TAC 0.69 [95% CI: 0.54 to 0.88]; CAC 0.89 [95% CI: 0.78 to 1.02]), whereas calcification was more prevalent in NCBP users among the 2,181 women <65 years of age (AVC 4.00 [95% CI: 2.33 to 6.89]; AVRC 1.92 [95% CI: 1.42 to 2.61]; MAC 2.35 [95% CI: 1.12 to 4.84]; TAC 2.17 [95% CI: 1.49 to 3.15]; CAC 1.23 [95% CI: 0.97 to 1.57]).
CONCLUSIONS: among women in the diverse MESA cohort, NCBPs were associated with decreased prevalence of cardiovascular calcification in older subjects but more prevalent cardiovascular calcification in younger ones. Further study is warranted to clarify these age-dependent NCBP effects.
Authors:
Sammy Elmariah; Joseph A C Delaney; Kevin D O'Brien; Matthew J Budoff; Jens Vogel-Claussen; Valentin Fuster; Richard A Kronmal; Jonathan L Halperin
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  56     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-12     Completed Date:  2011-01-11     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1752-9     Citation Subset:  AIM; IM    
Copyright Information:
2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
African Americans
Aged
Aged, 80 and over
Asian Americans
Atherosclerosis / chemically induced,  ethnology*,  radiography
Bone Density Conservation Agents / adverse effects
Calcinosis / chemically induced,  ethnology*,  radiography
Diphosphonates / adverse effects*
European Continental Ancestry Group
Female
Follow-Up Studies
Heart Valve Diseases / chemically induced,  ethnology*
Hispanic Americans
Humans
Middle Aged
Prevalence
Prognosis
Retrospective Studies
Risk Factors
United States / epidemiology
Vascular Diseases / chemically induced,  ethnology*,  radiography
Grant Support
ID/Acronym/Agency:
N01 HC095159/HC/NHLBI NIH HHS; N01 HC095160/HC/NHLBI NIH HHS; N01 HC095161/HC/NHLBI NIH HHS; N01 HC095162/HC/NHLBI NIH HHS; N01 HC095163/HC/NHLBI NIH HHS; N01 HC095164/HC/NHLBI NIH HHS; N01 HC095165/HC/NHLBI NIH HHS; N01 HC095166/HC/NHLBI NIH HHS; N01 HC095167/HC/NHLBI NIH HHS; N01 HC095168/HC/NHLBI NIH HHS; N01 HC095169/HC/NHLBI NIH HHS; N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; R01 HL071739-01/HL/NHLBI NIH HHS; R01 HL071739-02/HL/NHLBI NIH HHS; R01 HL071739-03/HL/NHLBI NIH HHS; R01 HL071739-04/HL/NHLBI NIH HHS; T32 HL007824/HL/NHLBI NIH HHS; T32 HL007824-09/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Diphosphonates
Comments/Corrections

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