Document Detail

Bisphosphonate drug holiday: choosing appropriate candidates.
MedLine Citation:
PMID:  23296595     Owner:  NLM     Status:  MEDLINE    
Osteoporosis related fractures contribute to morbidity and mortality in U.S. patients, placing a heavy financial burden on society. Randomized clinical trials involving over 30,000 subjects have established bisphosphonates' efficacy in reducing the incidence of fragility fractures. However, as bisphosphonates are retained for years in the skeleton, reports of adverse events from prolonged use are surfacing in the literature, namely, esophageal cancer, atrial fibrillation, osteonecrosis of the jaw, and atypical fracture development. The concept of a drug holiday has been proposed to potentially reduce incidence of these adverse events. This review will highlight the benefits and risks of bisphosphonate therapy and discuss the extension data available from the bisphosphonate trials. As randomized clinical trial evidence is not yet available on who may qualify for drug holiday, this review will provide suggestions for clinicians on identification of possible candidates and monitoring during a bisphosphonate drug holiday.
Cynthia Ro; Odelia Cooper
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current osteoporosis reports     Volume:  11     ISSN:  1544-2241     ISO Abbreviation:  Curr Osteoporos Rep     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-28     Completed Date:  2013-08-30     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101176492     Medline TA:  Curr Osteoporos Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-51     Citation Subset:  IM    
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MeSH Terms
Atrial Fibrillation / chemically induced,  epidemiology
Bisphosphonate-Associated Osteonecrosis of the Jaw / epidemiology
Diphosphonates / adverse effects*,  therapeutic use*
Esophageal Neoplasms / chemically induced,  epidemiology
Osteoporosis / complications,  drug therapy*
Osteoporotic Fractures / epidemiology,  prevention & control*
Patient Selection*
Risk Assessment
Grant Support
Reg. No./Substance:

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