Document Detail


Bisphenol A in human placental and fetal liver tissues collected from Greater Montreal area (Quebec) during 1998-2008.
MedLine Citation:
PMID:  22682542     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this study, the presence of bisphenol A (BPA) in human placental and fetal liver samples collected from 1998 to 2008 was investigated to provide a more detailed analysis of the transfer of BPA across the placenta and fetal exposure to BPA. The average concentrations in placental samples were 12.6ngg(-1) for free BPA, 17.2ngg(-1) for BPA-glu, and 30.2ngg(-1) for total BPA. The highest concentrations in placental samples were 165ngg(-1) for free BPA, 178ngg(-1) for BPA-glu, and 280ngg(-1) for total BPA. Samples with higher levels of BPA-glu had higher levels of free BPA in general. Fetal age was observed to have a significant effect on BPA-glu levels in placental samples, but not on free or total BPA. The percentages of free BPA relative to total BPA for the placental samples varied considerably from 4.2% to 100%, suggesting that the ability of maternal liver and/or the placenta to conjugate BPA is highly variable during early to mid-gestation. The average concentrations in fetal liver samples were 9.02ngg(-1) for free BPA, 19.1ngg(-1) for BPA-glu, and 25.8ngg(-1) for total BPA. The highest concentrations in fetal liver samples were 37.7ngg(-1) for free BPA, 93.9ngg(-1) for BPA-glu, and 123ngg(-1) for total BPA. The percentages of free BPA level relative to total BPA for all fetal liver samples varied from 12.4% to 99.1%, indicating extensive variability in the ability of the human feto-placental unit to glucuronidate BPA.
Authors:
Xu-Liang Cao; Jie Zhang; Cynthia G Goodyer; Stephen Hayward; Gerard M Cooke; Ivan H A Curran
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-7
Journal Detail:
Title:  Chemosphere     Volume:  -     ISSN:  1879-1298     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Food Directorate, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, Ontario, Canada K1A 0K9.
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