| Bisphenol A in human placental and fetal liver tissues collected from Greater Montreal area (Quebec) during 1998-2008. | |
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MedLine Citation:
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PMID: 22682542 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study, the presence of bisphenol A (BPA) in human placental and fetal liver samples collected from 1998 to 2008 was investigated to provide a more detailed analysis of the transfer of BPA across the placenta and fetal exposure to BPA. The average concentrations in placental samples were 12.6ngg(-1) for free BPA, 17.2ngg(-1) for BPA-glu, and 30.2ngg(-1) for total BPA. The highest concentrations in placental samples were 165ngg(-1) for free BPA, 178ngg(-1) for BPA-glu, and 280ngg(-1) for total BPA. Samples with higher levels of BPA-glu had higher levels of free BPA in general. Fetal age was observed to have a significant effect on BPA-glu levels in placental samples, but not on free or total BPA. The percentages of free BPA relative to total BPA for the placental samples varied considerably from 4.2% to 100%, suggesting that the ability of maternal liver and/or the placenta to conjugate BPA is highly variable during early to mid-gestation. The average concentrations in fetal liver samples were 9.02ngg(-1) for free BPA, 19.1ngg(-1) for BPA-glu, and 25.8ngg(-1) for total BPA. The highest concentrations in fetal liver samples were 37.7ngg(-1) for free BPA, 93.9ngg(-1) for BPA-glu, and 123ngg(-1) for total BPA. The percentages of free BPA level relative to total BPA for all fetal liver samples varied from 12.4% to 99.1%, indicating extensive variability in the ability of the human feto-placental unit to glucuronidate BPA. |
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Authors:
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Xu-Liang Cao; Jie Zhang; Cynthia G Goodyer; Stephen Hayward; Gerard M Cooke; Ivan H A Curran |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-7 |
Journal Detail:
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Title: Chemosphere Volume: - ISSN: 1879-1298 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0320657 Medline TA: Chemosphere Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Food Directorate, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, Ontario, Canada K1A 0K9. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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