Document Detail

Bisphenol-A exposure during pregnancy and lactation affects maternal behavior in rats.
MedLine Citation:
PMID:  15811589     Owner:  NLM     Status:  MEDLINE    
In mammals, endogenous estrogens are crucial for sexual differentiation during the perinatal period, and the modulation in adulthood of many neuroendocrine and behavioral functions involved in reproduction. In rats, the estrogenic environment during pregnancy and lactation affects directly maternal behavior. This experiment was aimed to test whether the exposure to the estrogenic compound bisphenol-A (BPA; 0.040 mg/kg/die, orally) of adult female rats, from mating to weaning of the pups, could alter maternal behavior. An appropriate methodology was applied to reveal differences in the behavior of dams directed to male and female pups, testing the dams on postnatal days 3-4 and 8-9. Results show different maternal behavioral patterns towards male and female pups of control mothers, with more ano-genital licking to males than to females. Exposure of mothers to BPA modified their behavior, reducing specific components of maternal behavior, both active and passive, irrespective of the sex of pups and the period of observation. This experiment shows that maternal behavior is affected by a prolonged exposure to a low dose of BPA during pregnancy and lactation, thus suggesting an effect on neural circuits in adulthood.
Daniele Della Seta; Isabelle Minder; Francesco Dessì-Fulgheri; Francesca Farabollini
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-12-18
Journal Detail:
Title:  Brain research bulletin     Volume:  65     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-06     Completed Date:  2005-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
Department of Physiology, Section of Neuroscience and Applied Physiology, University of Siena, 53100 Siena, Italy.
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MeSH Terms
Behavior, Animal / drug effects
Dose-Response Relationship, Drug
Estrogens, Non-Steroidal / pharmacology*
Lactation / drug effects*
Maternal Behavior / drug effects*
Phenols / pharmacology*
Prenatal Exposure Delayed Effects*
Rats, Sprague-Dawley
Sex Differentiation / drug effects
Sex Ratio
Sexual Behavior, Animal / drug effects
Statistics, Nonparametric
Reg. No./Substance:
0/Estrogens, Non-Steroidal; 0/Phenols; 80-05-7/bisphenol A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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