Document Detail

Bisphenol-A and disparities in birth outcomes: a review and directions for future research.
MedLine Citation:
PMID:  19587689     Owner:  NLM     Status:  MEDLINE    
Racial disparities in pregnancy outcome in the United States are significant, persistent and costly, but the causes are poorly understood. We propose that disproportionate exposure of African-American women to environmental endocrine disrupting compounds (EDCs) may contribute to birth outcome disparities. Marked racial segregation, as well as health behaviors associated with poverty could result in differences in exposure to particular EDCs. One EDC that has aroused concern in recent years is bisphenol-A (BPA), a widely used industrial plasticizer with known estrogenic properties. Published studies indicate that excessive BPA exposure is associated with reduced fetal survival, as well as reductions in maternal weight and fetal body weight. Related findings include adverse effects of BPA exposure on ovarian function, mammary gland development, earlier age of puberty onset and some metabolic parameters. However, these findings are largely limited to experimental animal studies, and need to be validated in human populations. Our review supports the need to move beyond the currently dominant toxicological approach to examining the effects of BPA exposure, and rely more on observational human studies and epidemiological methods. Many of the risk factors for racial disparities in pregnancy outcome are global or difficult to modify, but exposure to BPA is a potentially malleable risk factor. If BPA contributes to racial disparities in pregnancy outcome, there are important implications for prevention. It is our hope that this review will stimulate further research in this important and neglected area.
N Ranjit; K Siefert; V Padmanabhan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-07-09
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-29     Completed Date:  2010-05-13     Revised Date:  2014-05-27    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2-9     Citation Subset:  IM    
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MeSH Terms
African Americans*
Benzhydryl Compounds
Endocrine Disruptors / adverse effects
Environmental Exposure / adverse effects*
Health Status Disparities*
Phenols / adverse effects*
Pregnancy Complications / chemically induced*,  ethnology*
Pregnancy Outcome
Prenatal Exposure Delayed Effects
Grant Support
1P20RR020682-01/RR/NCRR NIH HHS; 1P50HD38986-01/HD/NICHD NIH HHS; R01 ES017005/ES/NIEHS NIH HHS
Reg. No./Substance:
0/Benzhydryl Compounds; 0/Endocrine Disruptors; 0/Phenols; MLT3645I99/bisphenol A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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