| Bisphenol-A and disparities in birth outcomes: a review and directions for future research. | |
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MedLine Citation:
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PMID: 19587689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Racial disparities in pregnancy outcome in the United States are significant, persistent and costly, but the causes are poorly understood. We propose that disproportionate exposure of African-American women to environmental endocrine disrupting compounds (EDCs) may contribute to birth outcome disparities. Marked racial segregation, as well as health behaviors associated with poverty could result in differences in exposure to particular EDCs. One EDC that has aroused concern in recent years is bisphenol-A (BPA), a widely used industrial plasticizer with known estrogenic properties. Published studies indicate that excessive BPA exposure is associated with reduced fetal survival, as well as reductions in maternal weight and fetal body weight. Related findings include adverse effects of BPA exposure on ovarian function, mammary gland development, earlier age of puberty onset and some metabolic parameters. However, these findings are largely limited to experimental animal studies, and need to be validated in human populations. Our review supports the need to move beyond the currently dominant toxicological approach to examining the effects of BPA exposure, and rely more on observational human studies and epidemiological methods. Many of the risk factors for racial disparities in pregnancy outcome are global or difficult to modify, but exposure to BPA is a potentially malleable risk factor. If BPA contributes to racial disparities in pregnancy outcome, there are important implications for prevention. It is our hope that this review will stimulate further research in this important and neglected area. |
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Authors:
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N Ranjit; K Siefert; V Padmanabhan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2009-07-09 |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 30 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-29 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 2-9 Citation Subset: IM |
Affiliation:
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Michael and Susan Dell Center for Advancement of Healthy Living, University of Texas School of Public Health, Austin Regional Campus, Austin, TX, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Americans* Endocrine Disruptors / adverse effects Environmental Exposure / adverse effects* Female Health Status Disparities* Humans Phenols / adverse effects* Pregnancy Pregnancy Complications / chemically induced*, ethnology* Pregnancy Outcome Prenatal Exposure Delayed Effects |
| Grant Support | |
ID/Acronym/Agency:
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1P20RR020682-01/RR/NCRR NIH HHS; 1P50HD38986-01/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endocrine Disruptors; 0/Phenols; 80-05-7/bisphenol A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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