Document Detail

Bisphenol A diglycidyl ether (BADGE) migrating from packaging material 'disappears' in food: reaction with food components.
MedLine Citation:
PMID:  18569010     Owner:  NLM     Status:  MEDLINE    
Bisphenol A diglycidyl ether (BADGE) is widely used as a monomer for coatings and adhesives for food-contact applications. Previous publications indicate that, after migration from packaging into foodstuffs, BADGE undergoes various reactions with unidentified food components. In order to elucidate the fate of BADGE, losses were determined after incubation with different foodstuffs and food components. Food proteins were identified as the main reaction partner with BADGE. Adduct formation was found with nucleophilic side-chains of amino acids. In vitro, cysteine exhibited significant activity. The previously reported occurrence of methylthio-derivatives of BADGE in foodstuffs was shown to originate from the reaction of BADGE with methionine. BADGE-methylthio derivatives can, therefore, be used as marker substances in foodstuffs for protein reactions with BADGE. The reported results offer a new viewpoint on the evaluation of BADGE migration. The hydrolysis and hydrochlorination derivatives subject to European legislation make up only a fraction of the totally migrated BADGE, and a further concern is that the toxic or allergenic potential of the protein adducts are unknown.
H Petersen; A Biereichel; K Burseg; T J Simat; H Steinhart
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     Volume:  25     ISSN:  1944-0057     ISO Abbreviation:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-11-17     Revised Date:  2009-08-13    
Medline Journal Info:
Nlm Unique ID:  101485040     Medline TA:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Country:  England    
Other Details:
Languages:  eng     Pagination:  911-20     Citation Subset:  IM    
Central Institute of Medical Service German Bundeswehr, Kiel, Germany.
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MeSH Terms
Bisphenol A-Glycidyl Methacrylate / analysis*,  chemistry
Food Analysis / methods
Food Contamination / analysis*
Food Packaging* / methods
Food Preservation / methods
Time Factors
Reg. No./Substance:
1565-94-2/Bisphenol A-Glycidyl Methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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