Document Detail

Bisphenol-A differently affects estrogen receptors-alpha in estrous-cycling and lactating female rats.
MedLine Citation:
PMID:  11524155     Owner:  NLM     Status:  MEDLINE    
The effect of long-term exposure to bisphenol-A (BPA) on estrogen receptor-alpha (ER) immunoreactivity was studied in the medial preoptic area, arcuate nucleus and the ventromedial nucleus of the hypothalamus of estrous cycling and lactating female rats. Pregnant/lactating or estrous cycling rats were exposed to BPA (40 mg/Kg/day) or peanut oil. Lactating females showed fewer ER-immunoreactive cells than non-lactating females in the medial preoptic area and ventromedial nucleus of the hypothalamus. BPA induced an increase in ER-immunoreactive cells in the medial preoptic nucleus irrespective of lactation. BPA only induced a decrease in ER-immunoreactive cells in the arcuate nucleus of the lactating group; oil induced an increase in ER-immunoreactive cells in the lactating with respect to non-lactating group. The results demonstrate that exposure of adult females to BPA modifies the number of ERs.
A M Aloisi; D Della Seta; I Ceccarelli; F Farabollini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  310     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-28     Completed Date:  2001-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  IM    
Institute of Human Physiology, University of Siena, Via Aldo Moro, 53100, Siena, Italy.
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MeSH Terms
Brain Chemistry / drug effects
Brain Mapping
Cell Count
Estrogen Receptor alpha
Estrogens, Non-Steroidal / pharmacology*
Estrus / physiology*
Lactation / physiology*
Phenols / pharmacology*
Rats, Sprague-Dawley
Receptors, Estrogen / physiology*
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Estrogens, Non-Steroidal; 0/Phenols; 0/Receptors, Estrogen; 80-05-7/bisphenol A

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