Document Detail


Bisphenol-A and chlorinated derivatives in adipose tissue of women.
MedLine Citation:
PMID:  17689919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bisphenol-A (BPA) and chlorinated derivatives (Cl(x)BPA) were investigated in adipose tissue of women in Southeast Spain. BPA was above limit of detection (LOD) in 11 out of 20 samples (55%). Among Cl(x)BPA, Cl(2)BPA was the most frequent (80%) and abundant, constituting 94.6% of total chlorinated BPA in adipose tissue. Mean +/- S.D. of BPA, monochloro-BPA (ClBPA), dichloro-BPA (Cl(2)BPA), and trichloro-BPA (Cl(3)BPA) were 5.83 +/- 3.48, 3.05 +/- 0.28, 9.21 +/- 9.26, and 0.74 +/- 0.15 ng/g of adipose tissue, respectively. No tetrachloro-BPA (Cl(4)BPA) was found above LOD. There are no published data on BPA in human adipose tissue or on Cl(x)BPA in adipose tissue or blood, limiting comparisons. BPA levels were similar (w/w) to findings in blood (w/v) in other populations and below levels reported in placenta tissue (w/w). Because of the estrogen mimicking effects of BPA and its Cl(x)BPA, further research is needed to explore their combined effects on human health and trends in human exposure.
Authors:
M F Fernandez; J P Arrebola; J Taoufiki; A Navalón; O Ballesteros; R Pulgar; J L Vilchez; N Olea
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-26
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  24     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    2007 Aug-Sep
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Affiliation:
Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18071 Granada, Spain. marieta@ugr.es
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry*
Adult
Age Factors
Aged
Benzhydryl Compounds / analysis,  chemistry
Body Mass Index
Chlorophenols / analysis,  chemistry
Environmental Exposure / analysis*
Estrogens, Non-Steroidal / analysis,  chemistry
Female
Gas Chromatography-Mass Spectrometry / methods
Humans
Middle Aged
Molecular Structure
Overweight
Phenols / analysis*,  chemistry
Polychlorinated Biphenyls / analysis*,  chemistry
Reproducibility of Results
Spain
Chemical
Reg. No./Substance:
0/2,2-bis(3-chloro-4-hydroxyphenyl)propane; 0/2-(3-chloro-4-hydroxyphenyl)-2-(3,5-dichloro-4-hydroxyphenyl)propane; 0/2-(3-chloro-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propane; 0/Benzhydryl Compounds; 0/Chlorophenols; 0/Estrogens, Non-Steroidal; 0/Phenols; 0/Polychlorinated Biphenyls; 79-95-8/tetrachlorodian; 80-05-7/bisphenol A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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