| Bisphenol a: how the most relevant exposure sources contribute to total consumer exposure. | |
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MedLine Citation:
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PMID: 20136739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bisphenol A (BPA) is an endocrine disrupting chemical that is found in human urine throughout industrial societies around the globe. Consumer exposure pathways to BPA include packaged food, household dust, air, and dental fillings. To date, information on the relative contribution of the different pathways to total consumer exposure is lacking, but is key for managing substance-associated risks. We investigated the relative contributions of the pathways known to be most relevant for nine different consumer groups. Our results suggest that the most important pathways for infants and children are the use of polycarbonate (PC) baby bottles and for adults and teenagers the consumption of canned food. Dental surgery can also considerably contribute over a short time directly after the surgery. For infants fed with PC baby bottles with mean dose rates of 0.8 microg/kg(bw)/d the highest exposure dose rate was calculated. This dose rate is far below the tolerable daily intake of 50 microg/kg(bw)/d. However, it is of the same order of magnitude as recently reported concentrations that caused low-dose health effects in rodents. We find a pattern of falling exposure levels with rising age that is supported by urinary concentrations of BPA available for selected consumer groups. Similarly, the exposure levels we predict are confirmed by the levels reported in these studies. |
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Authors:
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Natalie von Goetz; Matthias Wormuth; Martin Scheringer; Konrad Hungerbühler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-29 |
Journal Detail:
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Title: Risk analysis : an official publication of the Society for Risk Analysis Volume: 30 ISSN: 1539-6924 ISO Abbreviation: Risk Anal. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-09-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109978 Medline TA: Risk Anal Country: United States |
Other Details:
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Languages: eng Pagination: 473-87 Citation Subset: IM |
Affiliation:
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Institute of Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland. natalie.von.goetz@chem.ethz.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Dust / analysis Endocrine Disruptors / analysis* Food Packaging* Food, Preserved / analysis* Fruit / chemistry Humans Phenols Polycarboxylate Cement Polymers / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Dust; 0/Endocrine Disruptors; 0/Phenols; 0/Polycarboxylate Cement; 0/Polymers; 25766-59-0/polycarbonate; 80-05-7/bisphenol A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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