| Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial. | |
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MedLine Citation:
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PMID: 18542839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chronic heart failure (CHF) is a widespread disease with severe quality of life impairment and a poor prognosis. Beta-blockers are the mainstay of CHF therapy; yet they are under-prescribed and under-dosed in clinical practice. This is particularly evident in elderly patients, which may be due to a fear of side-effects or intolerance. Beta-blockers have further not been adequately tested in patients with diastolic CHF, which is particularly common in elderly patients. Finally, comparative data on the use of different beta-blockers in patients with CHF is scarce. AIM: To compare the tolerance of bisoprolol and carvedilol in elderly patients with CHF. METHODS: CIBIS-ELD is an investigator-initiated, multi-centre, 1:1 randomised, double-blind, phase III trial comparing bisoprolol and carvedilol in patients >or=65 years with systolic or diastolic CHF. Recruitment started in April 2005 and is anticipated to be completed by April 2008 with at least 800 patients enrolled. PERSPECTIVE: This is the first large scale head to head beta-blockers trial in an elderly population with CHF. Besides determining which of two standard beta-blockers is best tolerated in elderly patients with systolic or diastolic CHF, we expect to gain further insight into the treatment of the particular population of patients with diastolic CHF. |
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Authors:
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Hans-Dirk Düngen; Svetlana Apostolović; Simone Inkrot; Elvis Tahirović; Florian Krackhardt; Milan Pavlović; Biljana Putniković; Mitja Lainscak; Götz Gelbrich; Frank Edelmann; Rolf Wachter; Thomas Eschenhagen; Finn Waagstein; Ferenc Follath; Mathias Rauchhaus; Wilhelm Haverkamp; Karl-Josef Osterziel; Rainer Dietz; |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-06-09 |
Journal Detail:
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Title: Clinical research in cardiology : official journal of the German Cardiac Society Volume: 97 ISSN: 1861-0692 ISO Abbreviation: - Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-03 Completed Date: 2008-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264123 Medline TA: Clin Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 578-86 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Competence Network Heart Failure, Campus Virchow-Klinkum, Charité-Universitätsmedizin, Berlin, Germany. hans-dirk.duengen@charite.de |
| Data Bank Information | |
Bank Name/Acc. No.:
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ISRCTN/ISRCTN34827306 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Age Distribution Aged Bisoprolol / therapeutic use* Carbazoles / therapeutic use* Double-Blind Method Drug Tolerance Female Heart Failure / drug therapy*, epidemiology* Humans Male Propanolamines / therapeutic use* Randomized Controlled Trials as Topic* Research Design Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 66722-44-9/Bisoprolol; 72956-09-3/carvedilol |
| Investigator | |
Investigator/Affiliation:
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Hans-Jürgen Becker / ; Hans-Dirk Düngen / ; Thomas Eschenhagen / ; Roland Hardt / ; Friedrich Luft / ; Bernhard Rauch / ; Elisabeth Steinhagen-Thiessen / ; Ruth Strasser / ; Finn Waagstein / ; Ulrike Bauer / ; Stephan Beckmann / ; Jürgen Waigand / ; Georg Ertl / ; Ferenc Follath / ; Thomas Meinertz / ; S Baumbach / ; St Beckmann / ; St Czischke / ; W Dausch / ; H-Ch Deyda / ; A Dietze-Richter / ; H D Düngen / ; R Erbel / ; E Fleck / ; E Frohburg / ; Ch Gerischer / ; O Hagen / ; F Hartmannn / ; J Heckmann / ; J Honneth / ; H-U Kreider-Stempfle / ; I Kruck / ; H Leinberger / ; A Mügge / ; E Müller / ; M Oeff / ; B Pieske / ; N Prokynitopoulos / ; H-E Sarninghausen / ; Ch Schmitt / ; K-H Schöll / ; R-J Schulz / ; H-Y Sohn / ; R Strasser / ; H Streich / ; J Taggeselle / ; P Weismüller / ; S Zimmermann / ; R Zotz / ; S Apostolović / ; S Catović / ; V Celić / ; S Dimković / ; D Kosević / ; M Krotin / ; M Miloradović / ; J Milosavljević / ; Z Naumović / ; M Pavlović / ; V Petrović / ; B Putniković / ; D Sakac / ; N Trifunović / ; Z Vasiljević / ; S Zivković / ; M Lainscak / ; D Kovac / ; A Marolt / ; N Skrabl-Mocnik / ; A Bosković / ; B Knezević / |
| Comments/Corrections | |
Comment In:
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Clin Res Cardiol. 2008 Sep;97(9):575-7
[PMID:
18536866
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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