Document Detail


Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial.
MedLine Citation:
PMID:  18542839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic heart failure (CHF) is a widespread disease with severe quality of life impairment and a poor prognosis. Beta-blockers are the mainstay of CHF therapy; yet they are under-prescribed and under-dosed in clinical practice. This is particularly evident in elderly patients, which may be due to a fear of side-effects or intolerance. Beta-blockers have further not been adequately tested in patients with diastolic CHF, which is particularly common in elderly patients. Finally, comparative data on the use of different beta-blockers in patients with CHF is scarce.
AIM: To compare the tolerance of bisoprolol and carvedilol in elderly patients with CHF.
METHODS: CIBIS-ELD is an investigator-initiated, multi-centre, 1:1 randomised, double-blind, phase III trial comparing bisoprolol and carvedilol in patients >or=65 years with systolic or diastolic CHF. Recruitment started in April 2005 and is anticipated to be completed by April 2008 with at least 800 patients enrolled.
PERSPECTIVE: This is the first large scale head to head beta-blockers trial in an elderly population with CHF. Besides determining which of two standard beta-blockers is best tolerated in elderly patients with systolic or diastolic CHF, we expect to gain further insight into the treatment of the particular population of patients with diastolic CHF.
Authors:
Hans-Dirk Düngen; Svetlana Apostolović; Simone Inkrot; Elvis Tahirović; Florian Krackhardt; Milan Pavlović; Biljana Putniković; Mitja Lainscak; Götz Gelbrich; Frank Edelmann; Rolf Wachter; Thomas Eschenhagen; Finn Waagstein; Ferenc Follath; Mathias Rauchhaus; Wilhelm Haverkamp; Karl-Josef Osterziel; Rainer Dietz;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-06-09
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  97     ISSN:  1861-0692     ISO Abbreviation:  Clin Res Cardiol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-03     Completed Date:  2008-12-29     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  578-86     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Competence Network Heart Failure, Campus Virchow-Klinkum, Charité-Universitätsmedizin, Berlin, Germany. hans-dirk.duengen@charite.de
Data Bank Information
Bank Name/Acc. No.:
ISRCTN/ISRCTN34827306
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Age Distribution
Aged
Bisoprolol / therapeutic use*
Carbazoles / therapeutic use*
Double-Blind Method
Drug Tolerance
Female
Heart Failure / drug therapy*,  epidemiology*
Humans
Male
Propanolamines / therapeutic use*
Randomized Controlled Trials as Topic*
Research Design
Treatment Outcome
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol; 66722-44-9/Bisoprolol
Investigator
Investigator/Affiliation:
Hans-Jürgen Becker / ; Hans-Dirk Düngen / ; Thomas Eschenhagen / ; Roland Hardt / ; Friedrich Luft / ; Bernhard Rauch / ; Elisabeth Steinhagen-Thiessen / ; Ruth Strasser / ; Finn Waagstein / ; Ulrike Bauer / ; Stephan Beckmann / ; Jürgen Waigand / ; Georg Ertl / ; Ferenc Follath / ; Thomas Meinertz / ; S Baumbach / ; St Beckmann / ; St Czischke / ; W Dausch / ; H-Ch Deyda / ; A Dietze-Richter / ; H D Düngen / ; R Erbel / ; E Fleck / ; E Frohburg / ; Ch Gerischer / ; O Hagen / ; F Hartmannn / ; J Heckmann / ; J Honneth / ; H-U Kreider-Stempfle / ; I Kruck / ; H Leinberger / ; A Mügge / ; E Müller / ; M Oeff / ; B Pieske / ; N Prokynitopoulos / ; H-E Sarninghausen / ; Ch Schmitt / ; K-H Schöll / ; R-J Schulz / ; H-Y Sohn / ; R Strasser / ; H Streich / ; J Taggeselle / ; P Weismüller / ; S Zimmermann / ; R Zotz / ; S Apostolović / ; S Catović / ; V Celić / ; S Dimković / ; D Kosević / ; M Krotin / ; M Miloradović / ; J Milosavljević / ; Z Naumović / ; M Pavlović / ; V Petrović / ; B Putniković / ; D Sakac / ; N Trifunović / ; Z Vasiljević / ; S Zivković / ; M Lainscak / ; D Kovac / ; A Marolt / ; N Skrabl-Mocnik / ; A Bosković / ; B Knezević /
Comments/Corrections
Comment In:
Clin Res Cardiol. 2008 Sep;97(9):575-7   [PMID:  18536866 ]

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