| Bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors. | |
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MedLine Citation:
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PMID: 11140529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four new bisanthraquinone glycosides, S-(+)-skyrin-6-O-beta-glucopyranoside (1), R-(-)-skyrin-6-O-beta-glucopyranoside (2), S-(+)-skyrin-6-O-beta-xylopyranoside (3) and S-(+)-skyrin-6-O-beta-alpha-arabinofuranoside (4), have been isolated from an ethanol-water (1:1, v/v) dry extract of the aerial parts of Hypericum perforatum L. The structures were elucidated by spectroscopic methods, mainly NMR and mass spectrometry. Circular dichroism was used to determine their axial stereochemistry revealing 1 and 2 to be atropisomers. 1 and 2 inhibited [125I]sauvagine binding to corticotropin releasing hormone (CRH-1) receptors. |
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Authors:
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A Wirz; U Simmen; J Heilmann; I Calis; B Meier; O Sticher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Phytochemistry Volume: 55 ISSN: 0031-9422 ISO Abbreviation: Phytochemistry Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-03 Completed Date: 2001-03-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0151434 Medline TA: Phytochemistry Country: United States |
Other Details:
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Languages: eng Pagination: 941-7 Citation Subset: IM |
Affiliation:
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Department of Applied BioSciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation Amphibian Proteins Binding, Competitive Drug Interactions Hypericum / chemistry* Magnetic Resonance Spectroscopy Molecular Conformation Peptide Hormones Peptides / pharmacology Plants, Medicinal* Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*, metabolism Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Amphibian Proteins; 0/CRF receptor type 1; 0/Peptide Hormones; 0/Peptides; 0/Receptors, Corticotropin-Releasing Hormone; 0/Vasodilator Agents; 74434-59-6/sauvagine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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