| Bis-vinyl selenides obtained via iron(iii) catalyzed addition of PhSeSePh to alkynes: synthesis and antinociceptive activity. | |
| | |
MedLine Citation:
|
PMID: 23314037 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In the present study the synthesis and antinociceptive activity of bis-vinyl selenides, prepared via FeCl(3) promoted reaction addition of diorganyl dichalcogenides to alkynes, is described. The pharmacological results demonstrated that bis-vinyl selenides , , and elicited antinociceptive effect in the mouse formalin test. The antinociceptive effects of bis-vinyl selenides are not sensitive to electronic effects of the substituents on the aromatic ring directly bonded to the selenium atom. Bis-vinyl selenides and were the most promising molecules for pharmacological purposes since these bis-vinyl selenides were effective in both phases of the formalin test and against edema. A single dose of bis-vinyl selenides , , and did not cause acute toxicity in mice. |
| | |
Authors:
|
Glaubia Sartori; José S S Neto; Ana Paula Pesarico; Davi F Back; Cristina W Nogueira; Gilson Zeni |
Related Documents
:
|
7195767 - Kinetic analysis of compound i formation and the catalatic activity of chloroperoxidase. 23707917 - 2,5,6-trisubstituted imidazo[2,1-b][1,3,4]thiadiazoles: search for antihyperlipidemic a... 17661927 - Performance of ultraviolet photocatalytic oxidation for indoor air cleaning applications. 18161977 - Detection and mechanistic relevance of transient ligand radicals formed during [ru(bpy)... 11073687 - Asymmetric synthesis of the fully functional macrolide core of salicylihalamide: remote... 11097187 - Production of hydroxyl radical by the synergistic action of fungal laccase and aryl alc... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-14 |
Journal Detail:
|
Title: Organic & biomolecular chemistry Volume: - ISSN: 1477-0539 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Laboratório de Síntese, Reatividade, Avaliação Farmacológica e Toxicológica de Organocalcogênios, CCNE, UFSM, Santa Maria, Rio Grande do Sul 97105-900, Brazil. gzeni@ufsm.br. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Resveratrol inhibits human nasopharyngeal carcinoma cell growth via blocking pAkt/p70S6K signaling p...
Next Document: Biomonitoring of polycyclic aromatic hydrocarbon exposure in pregnant women in Trujillo, Peru - Comp...