| Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter. | |
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MedLine Citation:
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PMID: 20462759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of bis-azaaromatic quaternary ammonium compounds containing flexible polymethylenic linkers as well as conformationally restricted linkers were evaluated for their affinity for the blood-brain barrier choline transporter (BBB-ChT). The preliminary structure-activity relationships obtained from this study suggest that incorporating a linear, conformationally restricted linker into the molecule improves affinity for the BBB-ChT. |
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Authors:
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Guangrong Zheng; Zhenfa Zhang; Paul R Lockman; Werner J Geldenhuys; David D Allen; Linda P Dwoskin; Peter A Crooks |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-24 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 3208-10 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier* Ligands Membrane Transport Proteins / metabolism* Quaternary Ammonium Compounds / metabolism* Salts Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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U19 DA017548/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Membrane Transport Proteins; 0/Quaternary Ammonium Compounds; 0/Salts; 0/choline transporter |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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