Document Detail

Birthweight, early passive respiratory system mechanics, and ventilator requirements as predictors of outcome in premature infants with respiratory failure.
MedLine Citation:
PMID:  1852518     Owner:  NLM     Status:  MEDLINE    
Early respiratory mechanics have been reported to predict outcome in newborns with respiratory failure. However, it remains unknown whether measurements of pulmonary function add significantly to the predictive value of more readily available variables The present study was designed to answer this question. Passive respiratory system mechanics were measured by an airway occlusion technique in 104 ventilator-dependent premature infants between 6 and 48 hours of life and corrected for infant size. A ventilation index [FiO2 x mean airway pressure (MAP)] was calculated at the time of pulmonary function testing. Poor outcome was defined as death from respiratory failure or need for supplemental oxygen at 28 days. Stepwise logistic function regression examined whether ventilation index and respiratory mechanics added predictive power over and above birthweight. Five infants died, and 45 patients required supplemental oxygen at 28 days. Birthweight was a strong predictor and would have entered the logistic model first in any case. Ventilation index added significantly to the predictive model (P = 0.038). Respiratory system conductance (P = 0.15) and compliance (P = 0.93) entered on the third and last step, respectively. We conclude that in premature infants with respiratory failure, birthweight is a strong predictor of outcome. Early ventilator requirements but not respiratory system mechanics, add significantly to this predictive model.
H Kirpalani; B Schmidt; S Gaston; R Santos; R Wilkie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  10     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-21     Completed Date:  1991-08-21     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
Division of Neonatology, Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Birth Weight*
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases / physiopathology*,  therapy
Lung Compliance / physiology
Outcome and Process Assessment (Health Care)*
Predictive Value of Tests
Respiration, Artificial*
Respiratory Distress Syndrome, Newborn / physiopathology*,  therapy
Respiratory Function Tests
Respiratory Mechanics / physiology*
Comment In:
Pediatr Pulmonol. 1992 Jun;13(2):128-9   [PMID:  1495858 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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