Document Detail

Birthweight distribution in southern Chinese infants with symptomatic congenital heart disease.
MedLine Citation:
PMID:  12654142     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Western infants with congenital heart disease have frequently been reported to have a low birthweight for gestational age. Studies in Asian infants seem to be lacking in this area. This is the first extensive study presenting the birthweight distribution of Chinese newborns with symptomatic congenital heart disease. METHODS: The birth data of 454, mainly southern-Chinese infants with symptomatic cardiovascular defects, born between 1990 and 1995 and admitted to Grantham Hospital, Hong Kong in 1994 and 1995, were analysed retrospectively. Infants with (non)-genetic syndromes or other major extracardiac malformations were excluded. RESULTS: Fifteen per cent of all newborns had a birthweight below the reference mean of - 2 Z-score. After correction for length of gestation, no significant difference could be detected in birthweight between the cyanotic and acyanotic groups, nor between the different haemodynamic disturbances. Infants with atrial or ventricular septal defects, tetralogy of Fallot, pulmonary atresia with ventricular septal defect, heart with univentricular atrio-ventricular connection or double outlet right ventricle showed significant birthweight deficits. Transposition of the great arteries was not related to being small for gestational age. CONCLUSIONS: Similar to Western infants, prenatal growth impairment was a common feature in Chinese infants with symptomatic congenital heart disease. The birthweight distribution in Chinese might be comparable to that in Western populations. Exceptions are possibly the high frequency of low birthweight in Chinese newborns with atrial septal defect or a single-ventricle abnormality. Further studies on fetal anthropometry and haemodynamics are necessary to provide insight into the relation between cardiovascular malformations and being small for gestational age.
E G J Jacobs; M P Leung; J Karlberg
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  39     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-25     Completed Date:  2003-07-30     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  191-6     Citation Subset:  IM    
Department of Paediatrics, The University of Hong Kong, Grantham Hospital, Hong Kong SAR, China.
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MeSH Terms
Asian Continental Ancestry Group / genetics*
Birth Weight*
Body Height / physiology
Body Weight / physiology
Chi-Square Distribution
Child Development / physiology
China / epidemiology
Confidence Intervals
Gestational Age
Heart Defects, Congenital / diagnosis*,  ethnology*
Infant, Newborn
Infant, Small for Gestational Age / growth & development*
Retrospective Studies
Risk Factors
Severity of Illness Index
Sex Distribution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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