Document Detail

Birthdating studies reshape models for pituitary gland cell specification.
MedLine Citation:
PMID:  21262217     Owner:  NLM     Status:  MEDLINE    
The intermediate and anterior lobes of the pituitary gland are derived from an invagination of oral ectoderm that forms Rathke's pouch. During gestation proliferating cells are enriched around the pouch lumen, and they appear to delaminate as they exit the cell cycle and differentiate. During late mouse gestation and the postnatal period, anterior lobe progenitors re-enter the cell cycle and expand the populations of specialized, hormone-producing cells. At birth, all cell types are present, and their localization appears stratified based on cell type. We conducted a birth dating study of Rathke's pouch derivatives to determine whether the location of specialized cells at birth is correlated with the timing of cell cycle exit. We find that all of the anterior lobe cell types initiate differentiation concurrently with a peak between e11.5 and e13.5. Differentiation of intermediate lobe melanotropes is delayed relative to anterior lobe cell types. We discovered that specialized cell types are not grouped together based on birth date and are dispersed throughout the anterior lobe. Thus, the apparent stratification of specialized cells at birth is not correlated with cell cycle exit. Thus, the currently popular model of cell specification, dependent upon timing of extrinsic, directional gradients of signaling molecules, needs revision. We propose that signals intrinsic to Rathke's pouch are necessary for cell specification between e11.5 and e13.5 and that cell-cell communication likely plays an important role in regulating this process.
Shannon W Davis; Amanda H Mortensen; Sally A Camper
Related Documents :
972167 - Control of normal differentiation of myeloid leukemic cells. xi. induction of a specifi...
21505407 - Time-lapse live imaging of clonally related neural progenitor cells in the developing z...
3163997 - Retinol bound to physiological carrier molecules regulates growth and differentiation o...
20945337 - Tieg1 negatively controls the myoblast pool indispensable for fusion during myogenic di...
9878687 - Role of peroxide in ac electrical field exposure effects on friend murine erythroleukem...
4142077 - Similitudes and differences in the reactivity of the liver cell chromatin to thioacetam...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-22
Journal Detail:
Title:  Developmental biology     Volume:  352     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-28     Completed Date:  2011-05-26     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-27     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bone Morphogenetic Proteins / metabolism
Cell Cycle
Cell Differentiation
Cell Proliferation
Embryonic Stem Cells / cytology
Fibroblast Growth Factors / metabolism
Gestational Age
Models, Neurological*
Pituitary Gland / cytology,  embryology*,  physiology
Pituitary Gland, Anterior / cytology,  embryology,  physiology
Pituitary Hormones / biosynthesis
Signal Transduction
Grant Support
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Pituitary Hormones; 62031-54-3/Fibroblast Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation.
Next Document:  5-Hydroxytryptamine induces cyclooxygenase-2 in rat vascular smooth muscle cells: Mechanisms involvi...