| Birthdating studies reshape models for pituitary gland cell specification. | |
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MedLine Citation:
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PMID: 21262217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intermediate and anterior lobes of the pituitary gland are derived from an invagination of oral ectoderm that forms Rathke's pouch. During gestation proliferating cells are enriched around the pouch lumen, and they appear to delaminate as they exit the cell cycle and differentiate. During late mouse gestation and the postnatal period, anterior lobe progenitors re-enter the cell cycle and expand the populations of specialized, hormone-producing cells. At birth, all cell types are present, and their localization appears stratified based on cell type. We conducted a birth dating study of Rathke's pouch derivatives to determine whether the location of specialized cells at birth is correlated with the timing of cell cycle exit. We find that all of the anterior lobe cell types initiate differentiation concurrently with a peak between e11.5 and e13.5. Differentiation of intermediate lobe melanotropes is delayed relative to anterior lobe cell types. We discovered that specialized cell types are not grouped together based on birth date and are dispersed throughout the anterior lobe. Thus, the apparent stratification of specialized cells at birth is not correlated with cell cycle exit. Thus, the currently popular model of cell specification, dependent upon timing of extrinsic, directional gradients of signaling molecules, needs revision. We propose that signals intrinsic to Rathke's pouch are necessary for cell specification between e11.5 and e13.5 and that cell-cell communication likely plays an important role in regulating this process. |
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Authors:
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Shannon W Davis; Amanda H Mortensen; Sally A Camper |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-22 |
Journal Detail:
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Title: Developmental biology Volume: 352 ISSN: 1095-564X ISO Abbreviation: Dev. Biol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-28 Completed Date: 2011-05-26 Revised Date: 2012-11-26 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 215-27 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Human Genetics, University of Michigan Medical School, 4909 Buhl Building, 1241 East Catherine Street, Ann Arbor, MI 48109-5618, USA. davissw@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Morphogenetic Proteins / metabolism Cell Cycle Cell Differentiation Cell Proliferation Embryonic Stem Cells / cytology Female Fibroblast Growth Factors / metabolism Gestational Age Mice Models, Neurological* Pituitary Gland / cytology, embryology*, physiology Pituitary Gland, Anterior / cytology, embryology, physiology Pituitary Hormones / biosynthesis Pregnancy Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD034283/HD/NICHD NIH HHS; R01 HD034283-15/HD/NICHD NIH HHS; R01-HD34283/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bone Morphogenetic Proteins; 0/Pituitary Hormones; 62031-54-3/Fibroblast Growth Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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