Document Detail


Birthdating studies reshape models for pituitary gland cell specification.
MedLine Citation:
PMID:  21262217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intermediate and anterior lobes of the pituitary gland are derived from an invagination of oral ectoderm that forms Rathke's pouch. During gestation proliferating cells are enriched around the pouch lumen, and they appear to delaminate as they exit the cell cycle and differentiate. During late mouse gestation and the postnatal period, anterior lobe progenitors re-enter the cell cycle and expand the populations of specialized, hormone-producing cells. At birth, all cell types are present, and their localization appears stratified based on cell type. We conducted a birth dating study of Rathke's pouch derivatives to determine whether the location of specialized cells at birth is correlated with the timing of cell cycle exit. We find that all of the anterior lobe cell types initiate differentiation concurrently with a peak between e11.5 and e13.5. Differentiation of intermediate lobe melanotropes is delayed relative to anterior lobe cell types. We discovered that specialized cell types are not grouped together based on birth date and are dispersed throughout the anterior lobe. Thus, the apparent stratification of specialized cells at birth is not correlated with cell cycle exit. Thus, the currently popular model of cell specification, dependent upon timing of extrinsic, directional gradients of signaling molecules, needs revision. We propose that signals intrinsic to Rathke's pouch are necessary for cell specification between e11.5 and e13.5 and that cell-cell communication likely plays an important role in regulating this process.
Authors:
Shannon W Davis; Amanda H Mortensen; Sally A Camper
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-22
Journal Detail:
Title:  Developmental biology     Volume:  352     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-28     Completed Date:  2011-05-26     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-27     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Human Genetics, University of Michigan Medical School, 4909 Buhl Building, 1241 East Catherine Street, Ann Arbor, MI 48109-5618, USA. davissw@umich.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Morphogenetic Proteins / metabolism
Cell Cycle
Cell Differentiation
Cell Proliferation
Embryonic Stem Cells / cytology
Female
Fibroblast Growth Factors / metabolism
Gestational Age
Mice
Models, Neurological*
Pituitary Gland / cytology,  embryology*,  physiology
Pituitary Gland, Anterior / cytology,  embryology,  physiology
Pituitary Hormones / biosynthesis
Pregnancy
Signal Transduction
Grant Support
ID/Acronym/Agency:
R01 HD034283/HD/NICHD NIH HHS; R01 HD034283-15/HD/NICHD NIH HHS; R01-HD34283/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Pituitary Hormones; 62031-54-3/Fibroblast Growth Factors
Comments/Corrections

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